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钙化防御病例报告

A Case Report of Calciphylaxis.

作者信息

Hoang Kim, Lu Tien, Dang Alex, Matonis Danielle

机构信息

University of California, Irvine, School of Medicine, Irvine, CA.

University of California, Irvine Health, Department of Emergency Medicine, Orange, CA.

出版信息

J Educ Teach Emerg Med. 2025 Jul 31;10(3):V27-V30. doi: 10.21980/J8KW8V. eCollection 2025 Jul.

DOI:10.21980/J8KW8V
PMID:40766933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12320990/
Abstract

UNLABELLED

Calciphylaxis is a rare condition that is not well understood but is known to carry significant morbidity and mortality. We present a 44-year-old male with a history of end-stage renal disease on dialysis complaining of increasingly painful chronic wounds. The patient's physical exam was remarkable for ulcerated, bilateral anterior leg wounds with large areas of eschar along with purulent drainage. He was admitted to the hospital for intravenous antibiotics, wound care, and specialist consultation for treatment of calciphylaxis. This case report provides an overview of the key clinical features of calciphylaxis and reviews potential treatment strategies for this life-threatening condition.

TOPICS

Calciphylaxis, chronic kidney disease, end-stage renal disease, wound infection, wound care.

摘要

未标注

钙过敏是一种罕见病症,目前尚未被充分了解,但已知其具有较高的发病率和死亡率。我们报告一名44岁男性,有终末期肾病透析史,主诉慢性伤口疼痛日益加剧。患者体格检查发现双侧小腿前部有溃疡伤口,大面积焦痂并伴有脓性引流物。他因静脉使用抗生素、伤口护理以及接受钙过敏治疗的专科会诊而入院。本病例报告概述了钙过敏的关键临床特征,并回顾了针对这种危及生命病症的潜在治疗策略。

主题

钙过敏、慢性肾病、终末期肾病、伤口感染、伤口护理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62b6/12320990/4f89a9c2f1ae/jetem-10-3-v27f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62b6/12320990/4f89a9c2f1ae/jetem-10-3-v27f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62b6/12320990/4f89a9c2f1ae/jetem-10-3-v27f1.jpg

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本文引用的文献

1
Calciphylaxis and its diagnosis: A review.钙过敏症及其诊断:综述
J Family Med Prim Care. 2019 Sep 30;8(9):2763-2767. doi: 10.4103/jfmpc.jfmpc_588_19. eCollection 2019 Sep.
2
Calciphylaxis: Diagnosis, Pathogenesis, and Treatment.钙化防御:诊断、发病机制和治疗。
Adv Skin Wound Care. 2019 May;32(5):205-215. doi: 10.1097/01.ASW.0000554443.14002.13.
3
Calciphylaxis-as a drug induced adverse event.钙化防御——一种药物引起的不良反应。
Expert Opin Drug Saf. 2019 Jan;18(1):29-35. doi: 10.1080/14740338.2019.1559813. Epub 2018 Dec 24.
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Calciphylaxis.钙过敏症
N Engl J Med. 2018 May 3;378(18):1704-1714. doi: 10.1056/NEJMra1505292.
5
Calciphylaxis: risk factors, diagnosis, and treatment.钙过敏症:危险因素、诊断与治疗
Am J Kidney Dis. 2015 Jul;66(1):133-46. doi: 10.1053/j.ajkd.2015.01.034. Epub 2015 May 7.
6
Multi-intervention management of calciphylaxis: a report of 7 cases.钙化防御的多介入治疗:7 例报告。
Am J Kidney Dis. 2011 Dec;58(6):988-91. doi: 10.1053/j.ajkd.2011.06.022. Epub 2011 Aug 26.
7
Calciphylaxis: a still unmet challenge.钙化防御:一个仍未满足的挑战。
J Nephrol. 2011 Mar-Apr;24(2):142-8. doi: 10.5301/jn.2011.6366.
8
Should we perform surgical debridement in calciphylaxis?
Dermatol Surg. 2009 Mar;35(3):554-5. doi: 10.1111/j.1524-4725.2009.01091.x. Epub 2009 Feb 22.
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Calciphylaxis.钙过敏症
Dermatol Clin. 2008 Oct;26(4):557-68, ix. doi: 10.1016/j.det.2008.05.006.
10
Calciphylaxis: natural history, risk factor analysis, and outcome.钙过敏症:自然病史、危险因素分析及预后
J Am Acad Dermatol. 2007 Apr;56(4):569-79. doi: 10.1016/j.jaad.2006.08.065. Epub 2006 Dec 1.