Bapli Aloke, Lee Hyeryeong, Kang Minchae, Lee Jinmin, Lee Sang Hak
Department of Chemistry, Pusan National University, Busan 46241, Korea.
Institution for Functional Materials, Pusan National University, Busan 46241, Korea.
ACS Appl Bio Mater. 2025 Aug 18;8(8):7023-7036. doi: 10.1021/acsabm.5c00752. Epub 2025 Aug 6.
Silicon quantum dots (SiQDs@SPD) were synthesized via a hydrothermal method using -[3-(trimethoxysilyl)-propyl]-ethylenediamine as the silicon source and spermidine as the reducing agent. The production method was simple and environmentally friendly, producing spherical nanoparticles with a mean size of 2.8 nm. High-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, and fluorescence spectroscopy were used to further analyze SiQDs@SPD. In addition to displaying specific responses to the well-known neurotransmitter dopamine, the as-prepared SiQDs@SPD demonstrated strong antibacterial activity against () and (). Dopamine was quantified based on the quenching effect on the SiQDs@SPD emission at 400 nm. Furthermore, by examining the morphologies of and and the generation of reactive oxygen species (ROS), we found that these SiQDs@SPD shrank the bacteria and probably directly destroyed the bacterial structural integrity through the creation of singlet oxygen. It is possible that SiQDs@SPD can be used as a practical dopamine detection tool as well as a treatment for resistant bacterial infections.
以3-(三甲氧基硅基)丙基乙二胺为硅源、亚精胺为还原剂，通过水热法合成了硅量子点（SiQDs@SPD）。该制备方法简单且环保，能制备出平均尺寸为2.8 nm的球形纳米颗粒。利用高分辨率透射电子显微镜、X射线光电子能谱和荧光光谱对SiQDs@SPD进行了进一步分析。除了对著名的神经递质多巴胺表现出特异性响应外，所制备的SiQDs@SPD还对（）和（）表现出强大的抗菌活性。基于对SiQDs@SPD在4 nm处发射的猝灭效应来定量多巴胺。此外，通过观察（）和（）的形态以及活性氧（ROS）的产生，我们发现这些SiQDs@SPD使细菌收缩，并可能通过产生单线态氧直接破坏细菌的结构完整性。SiQDs@SPD有可能用作实用的多巴胺检测工具以及用于治疗耐药细菌感染。
