Brown Thomas C, McGee Aaron W
Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA; Department of Translational Neurosciences, University of Arizona College of Medicine - Phoenix, Phoenix, AZ 85004, USA.
Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA; Department of Translational Neurosciences, University of Arizona College of Medicine - Phoenix, Phoenix, AZ 85004, USA.
Curr Biol. 2025 Sep 8;35(17):4251-4258.e3. doi: 10.1016/j.cub.2025.07.026. Epub 2025 Aug 5.
Brief monocular deprivation during a developmentally critical period, but not thereafter, shifts cortical responses toward the non-deprived eye. The characteristics of neural circuitry that permit this experience-dependent plasticity are poorly understood. Here, we performed repeated calcium imaging at cellular resolution to track the tuning properties of populations of excitatory layer 2/3 neurons in the visual cortex of juvenile mice during the critical period, adult mice after the critical period, and adult nogo-66 receptor (ngr1) mutant mice that retain critical-period plasticity. The instability of tuning for populations of neurons, termed "representational drift," was significantly greater during the critical period than in adulthood. Adult ngr1 mutant mice displayed representational drift similar to that of juvenile mice. We propose that representational drift adapts the tuning of populations of neurons to recent experience during the critical period.
在发育关键期内短暂的单眼剥夺（而非在此之后）会使皮层反应偏向未被剥夺的眼睛。对于允许这种经验依赖性可塑性的神经回路特征，我们了解甚少。在这里，我们以细胞分辨率进行了重复的钙成像，以追踪关键期幼鼠、关键期后的成年小鼠以及保留关键期可塑性的成年无髓鞘蛋白-66受体（ngr1）突变小鼠视觉皮层中兴奋性第2/3层神经元群体的调谐特性。神经元群体调谐的不稳定性，即“表征漂移”，在关键期比成年期显著更大。成年ngr1突变小鼠表现出与幼鼠相似的表征漂移。我们提出，表征漂移在关键期使神经元群体的调谐适应最近的经验。
