Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA.
Nat Commun. 2021 Aug 27;12(1):5169. doi: 10.1038/s41467-021-25436-3.
To produce consistent sensory perception, neurons must maintain stable representations of sensory input. However, neurons in many regions exhibit progressive drift across days. Longitudinal studies have found stable responses to artificial stimuli across sessions in visual areas, but it is unclear whether this stability extends to naturalistic stimuli. We performed chronic 2-photon imaging of mouse V1 populations to directly compare the representational stability of artificial versus naturalistic visual stimuli over weeks. Responses to gratings were highly stable across sessions. However, neural responses to naturalistic movies exhibited progressive representational drift across sessions. Differential drift was present across cortical layers, in inhibitory interneurons, and could not be explained by differential response strength or higher order stimulus statistics. However, representational drift was accompanied by similar differential changes in local population correlation structure. These results suggest representational stability in V1 is stimulus-dependent and may relate to differences in preexisting circuit architecture of co-tuned neurons.
为了产生一致的感觉感知，神经元必须保持对感觉输入的稳定表示。然而，许多区域的神经元在几天内表现出逐渐的漂移。纵向研究发现，在视觉区域中，人工刺激在各次会议中存在稳定的反应，但尚不清楚这种稳定性是否扩展到自然刺激。我们对小鼠 V1 群体进行了慢性双光子成像，以直接比较数周内人工与自然视觉刺激的代表性稳定性。条纹的反应在各次会议中高度稳定。然而，对自然电影的神经反应在各次会议中表现出逐渐的代表性漂移。在皮层各层、抑制性中间神经元中都存在差异漂移，并且不能用不同的反应强度或高阶刺激统计来解释。然而，代表性漂移伴随着局部群体相关结构的相似差异变化。这些结果表明 V1 中的代表性稳定性是刺激依赖性的，可能与共调神经元的预先存在的电路结构差异有关。
