A latent profile analysis of cancer survivors' return to work adaptability and the associations between its' categories and financial toxicity.

To explore potential categories of cancer survivors' return to work adaptability, analyze associated influences, and identify the associations between different categories and financial toxicity. 412 cancer survivors were selected as participants. Data were collected using the general information questionnaire, the adaptability to return to work scale, and the comprehensive scores for financial toxicity based on patient-reported outcome measures. Cancer survivors' return to work adaptability was categorized using potential profile analysis. Financial toxicity was analyzed using multivariate logistic regression in potential categories. Cancer survivors' return to work adaptability was categorized into three groups, namely, "poor CSs-RTWA group", "moderate CSs-RTWA-adjustment group", and "high CSs-RTWA-harmonization group". Age, place of residence, education level, type of family, per capita monthly family income, main economic sources, nature of work, nature of work unit, occupation type, current working status, sick pay, financial toxicity were the factors influencing the potential categories of cancer survivors' return to work adaptability. The cancer survivors' return to work adaptability has obvious population heterogeneity and financial toxicity is an important factor influencing adaptability classification. We must focus on the cancer survivors in the group with poor adaptability. On the basis of identifying different potential categories of cancer survivors' return to work adaptability, reducing financial toxicity could be taken as an important intervention to precisely improve cancer survivors' return to work adaptability and help them achieve comprehensive physical, mental and social rehabilitation. In the future, large-scale and multi-center studies and stratified based on cancer types and cultural factors should be conducted to enhance the universality of the results.