Hu Xiaoyun, Dong Weiya, Zhao Hongya, Chen Ying, Shi Yue, Zhou Qigang, Huang Suyun
Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China.
Taizhou Second People's Hospital affiliated with Yangzhou University, Taizhou, 225300, Jiangsu, China.
Sci Rep. 2025 Aug 6;15(1):28703. doi: 10.1038/s41598-025-10152-5.
To explore potential categories of cancer survivors' return to work adaptability, analyze associated influences, and identify the associations between different categories and financial toxicity. 412 cancer survivors were selected as participants. Data were collected using the general information questionnaire, the adaptability to return to work scale, and the comprehensive scores for financial toxicity based on patient-reported outcome measures. Cancer survivors' return to work adaptability was categorized using potential profile analysis. Financial toxicity was analyzed using multivariate logistic regression in potential categories. Cancer survivors' return to work adaptability was categorized into three groups, namely, "poor CSs-RTWA group", "moderate CSs-RTWA-adjustment group", and "high CSs-RTWA-harmonization group". Age, place of residence, education level, type of family, per capita monthly family income, main economic sources, nature of work, nature of work unit, occupation type, current working status, sick pay, financial toxicity were the factors influencing the potential categories of cancer survivors' return to work adaptability. The cancer survivors' return to work adaptability has obvious population heterogeneity and financial toxicity is an important factor influencing adaptability classification. We must focus on the cancer survivors in the group with poor adaptability. On the basis of identifying different potential categories of cancer survivors' return to work adaptability, reducing financial toxicity could be taken as an important intervention to precisely improve cancer survivors' return to work adaptability and help them achieve comprehensive physical, mental and social rehabilitation. In the future, large-scale and multi-center studies and stratified based on cancer types and cultural factors should be conducted to enhance the universality of the results.
为探索癌症幸存者重返工作岗位适应性的潜在类别，分析相关影响因素，并确定不同类别与经济毒性之间的关联。选取412名癌症幸存者作为研究对象。采用一般信息问卷、重返工作岗位适应性量表以及基于患者报告结局指标的经济毒性综合评分来收集数据。运用潜在剖面分析对癌症幸存者重返工作岗位的适应性进行分类。在潜在类别中使用多因素逻辑回归分析经济毒性。癌症幸存者重返工作岗位的适应性分为三组，即“低适应性癌症幸存者-重返工作困难组”、“中等适应性癌症幸存者-重返工作调整组”和“高适应性癌症幸存者-重返工作协调组”。年龄、居住地点、教育程度、家庭类型、家庭月人均收入、主要经济来源、工作性质、工作单位性质、职业类型、当前工作状态、病假工资、经济毒性是影响癌症幸存者重返工作岗位适应性潜在类别的因素。癌症幸存者重返工作岗位的适应性存在明显的人群异质性，经济毒性是影响适应性分类的重要因素。我们必须关注适应性较差群体中的癌症幸存者。在明确癌症幸存者重返工作岗位适应性不同潜在类别的基础上，将降低经济毒性作为精准提高癌症幸存者重返工作岗位适应性、帮助他们实现身心和社会全面康复的重要干预措施。未来，应开展大规模、多中心研究，并基于癌症类型和文化因素进行分层，以提高研究结果的普遍性。
