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在转染的L细胞上针对H-2 I类抗原进行同基因免疫的小鼠会排斥移植的胚胎癌细胞。

Mice coisogenically immunized against H-2 class I antigens on transfected L cells reject transplanted embryonal carcinoma cells.

作者信息

Moser A R, Johnson L L, Dove W F

出版信息

Immunogenetics. 1985;22(6):533-41. doi: 10.1007/BF00430301.

DOI:10.1007/BF00430301
PMID:4077147
Abstract

Evidence is presented of the ability of H-2 class I antigens to function as teratocarcinoma transplantation (Gt) antigens. Coisogenic immunization against H-2 class I antigens expressed on transfected L cells is shown to induce resistance to embryonic carcinoma (EC) cell allografts. The Kb, Db, Dd, and, in appropriate recipients, Ld antigens can function as Gt antigens. The protocol presented may be useful for the molecular identification of other genes encoding histocompatibility antigens.

摘要

有证据表明H-2 I类抗原具有作为畸胎癌移植（Gt）抗原的功能。针对转染L细胞上表达的H-2 I类抗原进行同基因免疫，可诱导对胚胎癌（EC）细胞同种异体移植的抗性。Kb、Db、Dd以及在合适受体中Ld抗原均可作为Gt抗原发挥作用。所提出的方案可能有助于对编码组织相容性抗原的其他基因进行分子鉴定。

相似文献

1
Mice coisogenically immunized against H-2 class I antigens on transfected L cells reject transplanted embryonal carcinoma cells.在转染的L细胞上针对H-2 I类抗原进行同基因免疫的小鼠会排斥移植的胚胎癌细胞。
Immunogenetics. 1985;22(6):533-41. doi: 10.1007/BF00430301.
2
H-2 class I antigen expression on mouse teratocarcinoma cell lines.小鼠畸胎瘤细胞系上的H-2 I类抗原表达
Immunogenetics. 1985;22(6):543-52. doi: 10.1007/BF00430302.
3
Transfected H-2Kb gene as a cause of embryonal carcinoma cell rejection in vivo.转染的H-2Kb基因作为体内胚胎癌细胞排斥反应的一个原因。
Immunogenetics. 1989;29(4):269-72. doi: 10.1007/BF00717912.
4
Transfection and expression of syngeneic H-2 genes does not reduce malignancy of H-2 negative teratocarcinoma cells in the autologous host.同基因H-2基因的转染和表达不会降低H-2阴性畸胎瘤细胞在自体宿主中的恶性程度。
Cell Immunol. 1990 Jun;128(1):152-64. doi: 10.1016/0008-8749(90)90014-i.
5
Transfection of major histocompatibility complex class I and class II genes causes tumour rejection.转染主要组织相容性复合体I类和II类基因可导致肿瘤排斥。
J Immunogenet. 1989 Aug-Oct;16(4-5):343-9. doi: 10.1111/j.1744-313x.1989.tb00481.x.
6
MHC-unrestricted T-cell cytotoxicity against tumour cells.针对肿瘤细胞的主要组织相容性复合体非限制性T细胞细胞毒性
Immunology. 1988 Feb;63(2):233-9.
7
Strong teratocarcinoma transplantation loci, Gt-1 and Gt-2, flank H-2.强畸胎癌移植位点Gt-1和Gt-2位于H-2侧翼。
Immunogenetics. 1981;13(5):413-9. doi: 10.1007/BF00346022.
8
Overt expression of H-2 serotypes on EC cells is not necessary for host rejection.EC细胞上H-2血清型的过度表达对于宿主排斥反应并非必需。
Immunogenetics. 1984;19(4):343-7. doi: 10.1007/BF00345407.
9
Expression and T cell recognition of hybrid antigens with amino-terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens.具有由主要组织相容性复合体Qa-2区域编码的氨基末端结构域和移植抗原羧基末端的杂合抗原的表达及T细胞识别
J Exp Med. 1985 May 1;161(5):935-52. doi: 10.1084/jem.161.5.935.
10
Teratocarcinoma transplantation antigens are encoded in the H-2 region.畸胎癌移植抗原是在H-2区域编码的。
Immunogenetics. 1983;18(2):137-45. doi: 10.1007/BF00368542.

引用本文的文献

1
Resistance to 402AX teratocarcinoma involves immunity to minor histocompatibility antigens.对402AX畸胎癌的抗性涉及对次要组织相容性抗原的免疫。
Immunogenetics. 1987;26(1-2):1-5. doi: 10.1007/BF00345447.
2
MHC-unrestricted T-cell cytotoxicity against tumour cells.针对肿瘤细胞的主要组织相容性复合体非限制性T细胞细胞毒性
Immunology. 1988 Feb;63(2):233-9.
3
Embryonal carcinoma cells express Qa and Tla class I genes of the major histocompatibility complex.胚胎癌细胞表达主要组织相容性复合体的Qa和Tla I类基因。

本文引用的文献

1
The genetics of teratocarcinoma transplantation: tumor formation in allogeneic hosts by the embryonal carcinoma cell lines F9 and PCC3.畸胎癌移植的遗传学：胚胎癌细胞系 F9 和 PCC3 在同种异体宿主中的肿瘤形成。
Immunogenetics. 1978 Dec;7(1):103-15. doi: 10.1007/BF01843995.
2
DIFFERENTIAL RADIOSENSITIVITY OF FIRST AND SECOND-SET RESPONSES TO ALLOGENEIC AND XENOGENEIC SKIN GRAFTS IN SUBLETHALLY IRRADIATED MICE.亚致死剂量照射小鼠对同种异体和异种皮肤移植的初次和二次反应的差异放射敏感性
Transplantation. 1963 Oct;1:546-51.
3
Strong teratocarcinoma transplantation loci, Gt-1 and Gt-2, flank H-2.
Proc Natl Acad Sci U S A. 1989 Jul;86(13):5084-8. doi: 10.1073/pnas.86.13.5084.
4
H-2 class I and Gt (H-2) antigens are identical: evidence from H-2 mutant mice.H-2 I类抗原与Gt（H-2）抗原相同：来自H-2突变小鼠的证据。
Immunogenetics. 1986;23(4):271-3. doi: 10.1007/BF00373023.
强畸胎癌移植位点Gt-1和Gt-2位于H-2侧翼。
Immunogenetics. 1981;13(5):413-9. doi: 10.1007/BF00346022.
4
Teratocarcinoma transplantation rejection loci: genetic localization of the Gt-1 locus on chromosome 17 and the expression of alternate alleles.畸胎癌移植排斥位点：17号染色体上Gt-1位点的基因定位及等位基因的表达
Immunogenetics. 1981;13(5):405-12. doi: 10.1007/BF00346021.
5
Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex.针对小鼠MHC抗原的单克隆抗体。II. 针对H-2Ld抗原的抗体，小鼠主要组织相容性复合体第三个多态性位点的产物
J Immunol. 1980 Dec;125(6):2473-7.
6
Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.抗小鼠主要组织相容性复合体（MHC）抗原的单克隆抗体。III. 与H-2b单倍型抗原发生反应的杂交瘤抗体揭示了同种型表达的遗传控制。
J Immunol. 1981 Jan;126(1):317-21.
7
Expression of complete transplantation antigens by mammalian cells transformed with truncated class I genes.用截短的I类基因转化的哺乳动物细胞表达完整的移植抗原。
Nature. 1983 Feb 3;301(5899):388-94. doi: 10.1038/301388a0.
8
Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer.通过DNA介导的基因转移鉴定小鼠主要组织相容性复合体的I类基因。
Nature. 1982 Nov 18;300(5889):231-7. doi: 10.1038/300231a0.
9
Cellular enzyme-linked immunospecific assay (CELISA). I. A new micromethod that detects antibodies to cell-surface antigens.细胞酶联免疫特异性测定法（CELISA）。I. 一种检测细胞表面抗原抗体的新微量方法。
Hum Immunol. 1982 Aug;5(1):1-19. doi: 10.1016/0198-8859(82)90027-1.
10
Overt expression of H-2 serotypes on EC cells is not necessary for host rejection.EC细胞上H-2血清型的过度表达对于宿主排斥反应并非必需。
Immunogenetics. 1984;19(4):343-7. doi: 10.1007/BF00345407.