Zeng Qingfeng, Xiao Chunqing, Zeng Xianghui, Cao Gang, Liu Guosheng, Wu Jincheng, Lin Xiaomin, Deng Wenxin, Luo Jianping
Ganzhou Hospital of Traditional Chinese Medicine, Ganzhou, Jiangxi, China.
Ganzhou People's Hospital, Ganzhou, Jiangxi, China.
BMJ Nutr Prev Health. 2025 Jun 13;8(1):e001163. doi: 10.1136/bmjnph-2024-001163. eCollection 2025.
Gut microbiota is strongly associated with hypertension. The Dietary Index of Gut Microbiota (DI-GM) is a newly proposed indicator of the diversity of gut microbiota in the diet. However, the relationship between DI-GM and hypertension is unclear.
Data for this study were obtained from the National Health and Nutrition Examination Survey (2007-2020). Dietary data were used to calculate DI-GM and grouped into three tertile groups. Survey logistic regression and restricted cubic spline (RCS) were used to analyse the association between DI-GM and hypertension.
A total of 20 804 participants (age ≥20 years) were enrolled in the study. After adjusting for all covariates, the ORs for hypertension in the medium DI-GM group (second quartile, 4-5) and high DI-GM group (third quartile, >5) were 0.94 (95% CI: 0.83 to 1.06) and 0.87 (95% CI: 0.76 to 0.99) compared with the low DI-GM group (first quartile, <4). Additionally, results from the RCS analysis indicated a linear association between DI-GM and hypertension (p value for non-linearity=0.57).
Our findings suggest that higher DI-GM dietary patterns are associated with a lower prevalence of hypertension in a representative sample of US adults. These results suggest that dietary patterns characterised by a higher DI-GM may represent a potential strategy for the prevention of hypertension.
肠道微生物群与高血压密切相关。肠道微生物群饮食指数（DI-GM）是一种新提出的饮食中肠道微生物群多样性指标。然而，DI-GM与高血压之间的关系尚不清楚。
本研究数据来自国家健康与营养检查调查（2007 - 2020年）。饮食数据用于计算DI-GM，并分为三个三分位数组。采用调查逻辑回归和受限立方样条（RCS）分析DI-GM与高血压之间的关联。
本研究共纳入20804名参与者（年龄≥20岁）。在调整所有协变量后，与低DI-GM组（第一四分位数，<4）相比，中等DI-GM组（第二四分位数，4 - 5）和高DI-GM组（第三四分位数，>5）患高血压的OR值分别为0.94（95%CI：0.83至1.06）和0.87（95%CI：0.76至0.99）。此外，RCS分析结果表明DI-GM与高血压之间存在线性关联（非线性p值 = 0.57）。
我们的研究结果表明，在美国成年人的代表性样本中，较高的DI-GM饮食模式与较低的高血压患病率相关。这些结果表明，以较高DI-GM为特征的饮食模式可能是预防高血压的一种潜在策略。
