Lin Chia-Ling, Wu Hsueh-Ching, Yu Neng-Chun, Liu Yuan-Ching, Chiu I-Ying, Lee Yung-Yen, Chien Wu-Chien
Chang Gung University of Science and Technology, Gueishan, Taiwan.
Hsin Sheng Junior College of Medical Care and Management, Taoyuan, Taiwan.
BMJ Nutr Prev Health. 2025 Jun 18;8(1):e000995. doi: 10.1136/bmjnph-2024-000995. eCollection 2025.
To elucidate longitudinal changes of body composition among type 2 diabetes (T2D).
This was a retrospective study designed. A total of 6164 (mean age, 52.4±9.4 years) Taiwan T2D adults. The mean follow-up duration was 19.3±12.2 months. Body compositions were assessed using bioelectrical impedance analysis. Six body composition indicators were defined using body weight (BW), body mass index (BMI); appendicular skeletal muscle mass (ASM), skeletal muscle index (SMI); body fat mass (BFM) and percent body fat (PBF).
This study demonstrated that among individuals with T2D, their BW, BMI, ASM and SMI decreased progressively with age, with more pronounced annual declines observed in men compared with women. In contrast, changes in BFM and PBF exhibited a nonlinear trend: while both declined before the age of 65 years, they showed a shift towards stabilisation or increase after the age of 65 years. This upward trend was more evident in women compared with men, particularly for BFM.
Muscle tissue within the body composition of T2D patients experiences a decline with increasing age, while it is important to observe that adipose tissue demonstrates a rebound phenomenon after the age of 65 years.
阐明2型糖尿病（T2D）患者身体成分的纵向变化。
这是一项设计好的回顾性研究。共有6164名台湾T2D成年患者（平均年龄52.4±9.4岁）。平均随访时间为19.3±12.2个月。使用生物电阻抗分析评估身体成分。使用体重（BW）、体重指数（BMI）、四肢骨骼肌质量（ASM）、骨骼肌指数（SMI）、体脂肪量（BFM）和体脂百分比（PBF）定义六个身体成分指标。
本研究表明，在T2D患者中，他们的BW、BMI、ASM和SMI随年龄增长而逐渐下降，男性的年下降幅度比女性更明显。相比之下，BFM和PBF的变化呈现非线性趋势：在65岁之前两者均下降，但在65岁之后则趋于稳定或增加。这种上升趋势在女性中比男性更明显，尤其是BFM。
T2D患者身体成分中的肌肉组织随年龄增长而减少，同时需要注意的是，脂肪组织在65岁后会出现反弹现象。
