Stern N, Beahm E, McGinty D, Eggena P, Littner M, Nyby M, Catania R, Sowers J R
Hypertension. 1985 Nov-Dec;7(6 Pt 1):1023-9. doi: 10.1161/01.hyp.7.6.1023.
Increased plasma norepinephrine levels have been observed in some persons with early essential hypertension. Although both plasma norepinephrine level and mean arterial blood pressure rise with age, little is known about the state of catecholamine secretion in elderly patients with essential hypertension. We studied the 24-hour cycle levels of plasma norepinephrine, epinephrine, and dopamine in 12 elderly hypertensive subjects and 13 age-matched normotensive controls (mean ages, 63.8 +/- 1.2 yr and 64.8 +/- 1.8 yr [SEM] respectively). Blood samples were obtained at bihourly intervals from 0900 to 2100 hours and every 30 minutes from 2100 to 0900 hours, during which time sleep and breathing were continuously monitored. A circadian rhythm was displayed in both groups by plasma epinephrine levels (mesor, 49 +/- 2 pg/ml and 38 +/- 1 pg/ml; amplitude, 15 +/- 2 pg/ml and 11 +/- 1 pg/ml; acrophase, 12.20 +/- 0.40 hr and 14.41 +/- 0.34 hr in the normotensive and hypertensive groups respectively) but not by plasma norepinephrine or dopamine levels. During the 24-hour cycle plasma epinephrine, but not norepinephrine or dopamine, levels were positively related to mean arterial blood pressure (r = 0.60 for the normotensive subjects, r = 0.57 for the hypertensive subjects, p less than 0.01 for both).(ABSTRACT TRUNCATED AT 250 WORDS)
在一些早期原发性高血压患者中观察到血浆去甲肾上腺素水平升高。虽然血浆去甲肾上腺素水平和平均动脉血压都随年龄增长而升高，但对于老年原发性高血压患者儿茶酚胺分泌状态知之甚少。我们研究了12名老年高血压受试者和13名年龄匹配的血压正常对照者（平均年龄分别为63.8±1.2岁和64.8±1.8岁[标准误]）血浆去甲肾上腺素、肾上腺素和多巴胺的24小时循环水平。从09:00至21:00每两小时采集一次血样，从21:00至09:00每30分钟采集一次血样，在此期间持续监测睡眠和呼吸。两组血浆肾上腺素水平均呈现昼夜节律（正常血压组和高血压组的中值分别为49±2 pg/ml和38±1 pg/ml；振幅分别为15±2 pg/ml和11±1 pg/ml；峰相位分别为12.20±0.40小时和14.41±0.34小时），但血浆去甲肾上腺素或多巴胺水平未呈现昼夜节律。在24小时循环中，血浆肾上腺素水平而非去甲肾上腺素或多巴胺水平与平均动脉血压呈正相关（正常血压受试者r = 0.60，高血压受试者r = 0.57，两组p均<0.01）。（摘要截短为250字）
