Sowers J R, Vlachakis N
J Endocrinol Invest. 1984 Aug;7(4):341-5. doi: 10.1007/BF03351014.
Nocturnal and daytime recumbent secretory patterns of norepinephrine, epinephrine and dopamine were determined at 30 min intervals in 9 normotensive males. Plasma levels of dopamine as well as those of norepinephrine and epinephrine followed a circadian pattern in these recumbent males. Plasma levels of dopamine were more closely related to clock time (r = -0.54, p less than 0.001) than either norepinephrine or epinephrine levels. As for norepinephrine and epinephrine, the sleep period in all 9 males was characterized by a paucity of dopamine secretory peaks as well as lower mean dopamine levels than during the awake state. There was a strong relationship between the circadian changes in plasma dopamine levels and those of norepinephrine (r = 0.92) and epinephrine (r = 0.78) throughout the 24-h period of recumbency. These interrelationships are consistent with a common regulatory mechanism governing the sleep/wake and/or rest/activity in plasma catecholamine levels.
对9名血压正常的男性每隔30分钟测定一次去甲肾上腺素、肾上腺素和多巴胺的夜间及日间卧位分泌模式。在这些卧位男性中，多巴胺以及去甲肾上腺素和肾上腺素的血浆水平呈现昼夜节律模式。与去甲肾上腺素或肾上腺素水平相比，多巴胺的血浆水平与时钟时间的相关性更强（r = -0.54，p < 0.001）。至于去甲肾上腺素和肾上腺素，所有9名男性的睡眠期其特点是多巴胺分泌峰值较少，且平均多巴胺水平低于清醒状态。在整个24小时卧位期间，血浆多巴胺水平的昼夜变化与去甲肾上腺素（r = 0.92）和肾上腺素（r = 0.78）的昼夜变化之间存在很强的相关性。这些相互关系与一种共同的调节机制一致，该机制控制着血浆儿茶酚胺水平的睡眠/觉醒和/或休息/活动。
