Kjeldsen S E, Eide I, Aakesson I, Leren P
Scand J Clin Lab Invest. 1983 Jun;43(4):343-9.
In a recent study of 50-year-old men with long-standing, untreated essential hypertension we found increased arterial and venous plasma concentrations and arterial-venous differences of adrenaline (a-v) and noradrenaline (v-a) as compared to a matching normotensive control group. The aim of the present study was to investigate whether men of this age with hypertension of shorter duration and less severity than in the first study might also have increased plasma catecholamines. Twenty-three hypertensive and 17 age-matched normotensive control men were studied. The hypertensive ones had increased supine heart rate (P less than 0.05), arterial noradrenaline (P less than 0.01) and adrenaline (P less than 0.02) whereas venous catecholamines did not differ between the two groups. The a-v differences (means +/- SE) of adrenaline (78 +/- 14 vs 42 +/- 6 ng/l, P less than 0.05) were increased in the hypertensive compared to the normotensive group. In the hypertensive, the arterial plasma concentrations of the two catecholamines correlated positively (r = 0.71, P less than 0.001) as did the a-v differences (r = 0.54, P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
在一项针对患有长期未经治疗的原发性高血压的50岁男性的近期研究中，我们发现，与匹配的血压正常对照组相比，这些男性的动脉和静脉血浆中肾上腺素（a-v）和去甲肾上腺素（v-a）的浓度以及动静脉差值均有所增加。本研究的目的是调查，与第一项研究相比，年龄相同但高血压病程较短且病情较轻的男性血浆儿茶酚胺水平是否也会升高。我们对23名高血压男性和17名年龄匹配的血压正常对照男性进行了研究。高血压患者的仰卧心率升高（P<0.05），动脉去甲肾上腺素水平升高（P<0.01），肾上腺素水平升高（P<0.02），而两组的静脉儿茶酚胺水平没有差异。与血压正常组相比，高血压患者肾上腺素的动静脉差值（均值±标准误）升高（78±14 vs 42±6 ng/l，P<0.05）。在高血压患者中，两种儿茶酚胺的动脉血浆浓度呈正相关（r = 0.71，P<0.001），动静脉差值也呈正相关（r = 0.54，P<0.01）。（摘要截短至250字）
