De Mendonca M, Grichois M L, Garay R P, Sassard J, Ben-Ishay D, Meyer P
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4283-6. doi: 10.1073/pnas.77.7.4283.
Net Na+ and K+ fluxes were measured in Na+-loaded and K+-depleted erythrocytes of three varieties of genetically hypertensive rats. In Okamoto spontaneously hypertensive rats (4 and 10-12 weeks of age), Na+ extrusion was reduced as compared to normotensive controls (Wistar/Kyoto). Na+ extrusion was also reduced in the hypertension-prone substrain of the Hebrew University Sabra rats as compared to the Na+-resistant substrain. K+ fluxes were similar in both groups. In both Okamoto spontaneously hypertensive rats and the hypertension-prone substrain, hypertension was severe and developed rapidly. In the Lyon spontaneously hypertensive rats, in which the blood pressure elevation is less severe than in other genetically hypertensive rats, erythrocyte net Na+ extrusion was the same as in normotensive controls, but net K+ gain was slightly increased. These erythrocyte abnormalities, observed in three varieties of genetically transmitted hypertension of the rat, are in several aspects similar to those previously described in accelerated and benign human essential hypertension. Erythrocyte Na+ and K+ net flux alterations may thus represent biochemical markers of primary hypertension.
在三种遗传性高血压大鼠中，对钠负荷增加和钾缺乏的红细胞的净钠和钾通量进行了测量。在冈本自发性高血压大鼠（4周龄和10 - 12周龄）中，与血压正常的对照大鼠（Wistar/Kyoto）相比，钠的排出减少。与耐钠亚系相比，希伯来大学Sabra大鼠的高血压易感亚系中钠的排出也减少。两组的钾通量相似。在冈本自发性高血压大鼠和高血压易感亚系中，高血压都很严重且发展迅速。在里昂自发性高血压大鼠中，其血压升高程度不如其他遗传性高血压大鼠严重，红细胞净钠排出与血压正常的对照大鼠相同，但净钾摄取略有增加。在大鼠的三种遗传性高血压中观察到的这些红细胞异常，在几个方面与先前在加速性和良性人类原发性高血压中描述的异常相似。因此，红细胞钠和钾净通量的改变可能代表原发性高血压的生化标志物。
