Chen Zi-Rong, Wan Tsung-Yao, Chuang Lan-Hsin, Lai Chi-Chun, Hwang Yih-Shiou, Kuo Yu-Kai, Chen Ho-Min, Chang Po-Chun, Chen Hung-Chi, Liu Chun-Fu
Department of Family Medicine, Cheng Ching Hospital, Taichung, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
PLoS One. 2025 Aug 7;20(8):e0327354. doi: 10.1371/journal.pone.0327354. eCollection 2025.
This study aimed to investigate whether early axial length (AL) changes in the short term after 0.125% atropine treatment could predict long-term axial elongation in children with myopia.
This was a prospective cohort study involving children aged 5-15 years with myopia who were treated with 0.125% atropine for myopia control. AL was measured 1-2 months after starting treatment and then every 3 months for follow-up visits. Regression analysis was used to develop a model of AL changes with time. A generalized estimating equation (GEE) model was then used to identify correlations between the early AL changes and long-term AL changes.
Eighty eyes of 40 patients (mean age 8.4 years) were included in the final analysis. The estimation curve of AL changes with time indicated that the AL decreased at 67 days (the turning point in the regression model) after 0.125% atropine treatment and then increased gradually with time. Univariate GEE showed that a larger AL elongation in the initial 4 months was significantly associated with AL changes at 6 months (β = 0.354, P = 0.020, 6 ~ 12 months period from baseline) and 12 months (β = 0.560, P = 0.045, 6 ~ 18 months period from baseline) after that period in all myopic eyes.
The magnitude of AL elongation in the initial 4 months of 0.125% atropine treatment correlated positively with the further half-year and one-year AL changes. Identifying these changes may be useful for controlling refractory myopia in children.
本研究旨在探讨0.125%阿托品治疗后短期内早期眼轴长度（AL）变化是否可预测近视儿童的长期眼轴伸长。
这是一项前瞻性队列研究，纳入了5-15岁近视儿童，他们接受0.125%阿托品治疗以控制近视。在开始治疗后1-2个月测量眼轴长度，随后每3个月进行一次随访测量。采用回归分析建立眼轴长度随时间变化的模型。然后使用广义估计方程（GEE）模型确定早期眼轴长度变化与长期眼轴长度变化之间的相关性。
最终分析纳入了40例患者（平均年龄8.4岁）的80只眼。眼轴长度随时间变化的估计曲线表明，0.125%阿托品治疗后67天（回归模型中的转折点）眼轴长度下降，随后随时间逐渐增加。单变量GEE分析显示，在最初4个月内眼轴伸长幅度较大与此后所有近视眼中6个月（β = 0.354，P = 0.020，从基线起6至12个月）和12个月（β = 0.560，P = 0.045，从基线起6至18个月）的眼轴长度变化显著相关。
0.125%阿托品治疗最初4个月内眼轴伸长幅度与接下来半年和一年的眼轴长度变化呈正相关。识别这些变化可能有助于控制儿童难治性近视。
