Posso Agustin N, Cojuc-Konigsberg Gabriel, Mustoe Audrey, Mehdizadeh Morvarid, Foppiani Jose, Escobar-Domingo Maria J, Lin Samuel J, Lee Bernard T
Division of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Aesthetic Plast Surg. 2025 Aug 7. doi: 10.1007/s00266-025-05107-0.
Filler injections are one of the most common minimally invasive cosmetic procedures. Some of the related adverse effects remain unexplored, such as kidney-related complications. This systematic review aims to summarize the cases of patients who developed kidney disease after filler injections.
The study protocol followed the PRISMA guidelines. Multiple online databases were used in this review. Eligible studies included cases of patients who developed any kidney-related complication after filler injections. A two-stage screening process was conducted for study selection. Data extraction focused primarily on kidney complications.
Twenty-nine patients were identified, from 18 case reports and 4 case series. The most frequently injected anatomical site was the buttocks (72.41%, n=21). The three most identified fillers included silicone (51.72%, n=15), methacrylate (31.03%, n=9), and oil (17.24%, n=5). Notably, the status of the practitioner who administered the injections was reported as a non-medical professional in six articles. The most common reported kidney-related complication was chronic kidney disease (CKD), affecting 55.17% (n=16) of patients. Most patients received treatment through hydration (68.97%, n=20) and steroids (68.97%, n=20), while surgery was performed in 20.69% (n=6) of cases. After the renal complication, 37.93% (n=11) patients achieved remission, 20.69% (n=6) patients developed CKD, and 10.34% (n=3) patients died.
This study described 29 patients who developed renal complications after filler injections. The prevalence of unlicensed or unidentified practitioners performing these procedures could increase the risk of severe outcomes. This underscores the need for stringent regulations and education.
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
填充剂注射是最常见的微创美容手术之一。一些相关的不良反应仍未得到充分研究，比如与肾脏相关的并发症。本系统评价旨在总结填充剂注射后出现肾脏疾病的患者病例。
本研究方案遵循PRISMA指南。本评价使用了多个在线数据库。符合条件的研究包括填充剂注射后出现任何与肾脏相关并发症的患者病例。研究选择过程分两个阶段进行筛选。数据提取主要集中在肾脏并发症方面。
共识别出29例患者，来自18篇病例报告和4个病例系列。注射最频繁的解剖部位是臀部（72.41%，n = 21）。三种最常见的填充剂包括硅酮（51.72%，n = 15）、甲基丙烯酸酯（31.03%，n = 9）和油类（17.24%，n = 5）。值得注意的是，在6篇文章中，注射操作人员的身份被报告为非医学专业人员。报告的最常见的与肾脏相关的并发症是慢性肾脏病（CKD），影响了55.17%（n = 16）的患者。大多数患者通过补液（68.97%，n = 20）和使用类固醇（68.97%，n = 20）进行治疗，而20.69%（n = 6）的病例进行了手术。肾脏并发症发生后，37.93%（n = 11）的患者病情缓解，20.69%（n = 6）的患者发展为CKD，10.34%（n = 3）的患者死亡。
本研究描述了29例填充剂注射后出现肾脏并发症的患者。无执照或身份不明的操作人员进行这些手术的情况可能会增加严重后果的风险。这凸显了严格监管和教育的必要性。
本刊要求作者为每篇文章指定证据等级。有关这些循证医学评级的完整描述，请参阅目录或在线作者指南www.springer.com/00266 。
