Amato M, von Muralt G, Auf der Maur P
Helv Paediatr Acta. 1985 Sep;40(4):285-91.
The irradiation of jaundiced infants with fluorescent lights is currently the most common method of treating neonatal hyperbilirubinemia. To investigate whether phototherapy is capable of damaging the genetic material, peripheral lymphocytes of ten jaundiced newborns were studied. Chromosomal analyses were carried out before and after 24 h of treatment with double blue light phototherapy at wavelengths from 420 to 500 nm. Using the BrdU technique for chromosomal culture, no detectable aberrations on genetic material of circulating lymphocytes were observed. This study doesn't, however, exclude potential deleterious effects of phototherapy on other tissues such as skin fibroblasts or immature ovaries in female infants.
用荧光灯照射黄疸婴儿是目前治疗新生儿高胆红素血症最常用的方法。为了研究光疗是否会损害遗传物质，对10名黄疸新生儿的外周淋巴细胞进行了研究。在用波长为420至500nm的双蓝光光疗24小时前后进行了染色体分析。使用BrdU技术进行染色体培养，未观察到循环淋巴细胞遗传物质有可检测到的畸变。然而，这项研究并未排除光疗对其他组织如皮肤成纤维细胞或女婴未成熟卵巢的潜在有害影响。
