Development and Validation of Predictive Risk Scores for Ovarian Clear Cell Carcinoma: A Penalized Regression Model.

BACKGROUND

The precision management of ovarian clear cell carcinoma (OCCC) faces limitations due to the absence of personalized prognostic tools. This study aimed to establish predictive risk scores to enable effective stratification and tailored treatment of OCCC.

METHODS

Retrospective data from 206 OCCC patients treated between 2004 and 2019 at two hospitals were analyzed. Penalized regression models were utilized to develop three risk scores based on preoperative laboratory results and intraoperative findings. These scores underwent internal and external validation.

RESULTS

The median follow-up periods were 65.7 and 44.0 months for the derivation and validation cohorts, respectively. In internal validation with the derivation cohort, all three risk scores effectively identified the high-risk group for tumor recurrence. Upon validation with the external cohort, Risk Score 3, which incorporated variables selected in most cross-validations by the penalized regression (Elastic Net), distinctly differentiated the high- and low-risk groups (p = 0.03). Risk Score 2, consisting solely of preoperatively available variables, also demonstrated marginal significance (p = 0.08).

CONCLUSION

Our findings underscore the significance and utility of the developed risk scores in tailoring personalized treatments for patients with OCCC.