Boland C Richard, Yurgelun Matthew B
Division of GI, University of California San Diego School of Medicine, San Diego, California.
Dana-Farber Cancer Institute, Boston, Massachusetts.
Cell Mol Gastroenterol Hepatol. 2017 Feb 28;3(2):192-200. doi: 10.1016/j.jcmgh.2016.12.003. eCollection 2017 Mar.
Gastric cancer is a common disease worldwide, typically associated with acquired chronic inflammation in the stomach, related in most instances to infection by . A small percentage of cases occurs in familial clusters, and some of these can be linked to specific germline mutations. This article reviews the historical background to the current understanding of familial gastric cancer, focuses on the entity of hereditary diffuse gastric cancer, and also reviews the risks for gastric cancer related to a number of other familial genetic diseases.
胃癌是一种全球常见的疾病，通常与胃部获得性慢性炎症相关，在大多数情况下与……感染有关。一小部分病例以家族聚集形式出现，其中一些可与特定的种系突变相关联。本文回顾了目前对家族性胃癌认识的历史背景，重点关注遗传性弥漫性胃癌这一实体，并还回顾了与其他一些家族性遗传疾病相关的胃癌风险。
