Sundgren J E, Bodö P, Lundström I, Berggren A, Hellem S
J Biomed Mater Res. 1985 Jul-Aug;19(6):663-71. doi: 10.1002/jbm.820190606.
Auger electron spectroscopy together with scanning electron microscopy has been used to study the interface between stainless-steel implants and human tissue. The thickness and nature of the oxide layer on the implants have been found to depend on the location of the implants in the body. Before implantation, the oxide layer is about 50 A thick, consisting mainly of chromium oxide. For implants located in cortical bone the thickness of the interfacial oxide layer remains unaffected, while it increases by a factor of three to four on samples located in bone marrow. In both these cases calcium and phosphorus are incorporated in the oxides. Implants located in soft tissue have an interfacial oxide layer with a thickness of about one and one-half times that on an unimplanted sample. On these samples, calcium and phosphorus are not found, but occasionally sulfur is found in the oxide layer. All these samples originated from the oral region of the body; the reason for this finding, however, is not known at present time. The interactions between the implants and human tissues resulting in the observed changes of the implant surfaces are discussed in terms of oxygen pressures and metabolic activity.
俄歇电子能谱与扫描电子显微镜已被用于研究不锈钢植入物与人体组织之间的界面。已发现植入物上氧化层的厚度和性质取决于植入物在体内的位置。植入前，氧化层约50埃厚，主要由氧化铬组成。对于位于皮质骨中的植入物，界面氧化层的厚度保持不变，而对于位于骨髓中的样本，其厚度增加三到四倍。在这两种情况下，钙和磷都掺入了氧化物中。位于软组织中的植入物具有的界面氧化层厚度约为未植入样本的一倍半。在这些样本上，未发现钙和磷，但偶尔在氧化层中发现硫。所有这些样本都来自身体的口腔区域；然而，目前尚不清楚这一发现的原因。根据氧分压和代谢活性讨论了植入物与人体组织之间导致观察到的植入物表面变化的相互作用。
