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Cytotoxicity and Antiplatelet Activity of Cationic Antimicrobial Peptides of the Medicinal Leech Hirudo Medicinalis.

作者信息

Moroz Grigoriy D, Podoplelova Nadezhda A, Iudin Mikhail S, Alieva Sabina E, Varizhuk Anna M, Panteleev Mikhail A, Lazarev Vassili N, Panasenko Oleg M

机构信息

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia.

Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Science, Moscow, 109029, Russia.

出版信息

Cell Biochem Biophys. 2025 Aug 8. doi: 10.1007/s12013-025-01860-w.

DOI:10.1007/s12013-025-01860-w
PMID:40779125
Abstract
摘要

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本文引用的文献

1
Effects of Synthetic Short Cationic Antimicrobial Peptides on the Catalytic Activity of Myeloperoxidase, Reducing Its Oxidative Capacity.合成短阳离子抗菌肽对髓过氧化物酶催化活性的影响，降低其氧化能力。
Antioxidants (Basel). 2022 Dec 7;11(12):2419. doi: 10.3390/antiox11122419.
2
Effects of Medicinal Leech-Related Cationic Antimicrobial Peptides on Human Blood Cells and Plasma.水蛭相关阳离子抗菌肽对人血细胞和血浆的影响。
Molecules. 2022 Sep 9;27(18):5848. doi: 10.3390/molecules27185848.
3
Mode-of-Action of Antimicrobial Peptides: Membrane Disruption vs. Intracellular Mechanisms.
抗菌肽的作用机制：膜破坏与细胞内机制
Front Med Technol. 2020 Dec 11;2:610997. doi: 10.3389/fmedt.2020.610997. eCollection 2020.
4
Antimicrobial peptides: mechanism of action, activity and clinical potential.抗菌肽：作用机制、活性和临床潜力。
Mil Med Res. 2021 Sep 9;8(1):48. doi: 10.1186/s40779-021-00343-2.
5
Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields.抗菌肽：生物医药与制药领域的新希望。
Front Cell Infect Microbiol. 2021 Jun 14;11:668632. doi: 10.3389/fcimb.2021.668632. eCollection 2021.
6
The Microbiome Is a Source of New Antimicrobial Peptides.微生物组是新型抗菌肽的来源。
Int J Mol Sci. 2020 Sep 27;21(19):7141. doi: 10.3390/ijms21197141.
7
Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance.综合进化分析揭示具有有限耐药性的抗菌肽。
Nat Commun. 2019 Oct 4;10(1):4538. doi: 10.1038/s41467-019-12364-6.
8
Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens.药用蛭素抗菌肽缺乏毒性，代表了一种对抗抗生素耐药病原体的有前途的替代策略。
Eur J Med Chem. 2019 Oct 15;180:143-153. doi: 10.1016/j.ejmech.2019.06.080. Epub 2019 Jul 4.
9
Binding of Coagulation Factor XIII Zymogen to Activated Platelet Subpopulations: Roles of Integrin αIIbβ3 and Fibrinogen.凝血因子 XIII 酶原与活化血小板亚群的结合：整合素 αIIbβ3 和纤维蛋白原的作用。
Thromb Haemost. 2019 Jun;119(6):906-915. doi: 10.1055/s-0039-1683912. Epub 2019 Apr 1.
10
Alternatives to Conventional Antibiotics in the Era of Antimicrobial Resistance.抗微生物药物耐药时代的传统抗生素替代品。
Trends Microbiol. 2019 Apr;27(4):323-338. doi: 10.1016/j.tim.2018.12.010. Epub 2019 Jan 22.