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Energy Decomposition-Driven Design of Trop2-Targeting Peptide.

作者信息

Meng Yu-Chao, Liu He, Sun Bi-Shao, Liu Hong-Yuan, Li Hong-Wei, Liao Qiu-Yu, Huang Mouxin, Ouyang Qin

机构信息

Department of Medicinal Chemistry, Third Military Medical University, Chongqing, China.

出版信息

Cell Biochem Biophys. 2025 Aug 8. doi: 10.1007/s12013-025-01866-4.

DOI:10.1007/s12013-025-01866-4
PMID:40779128
Abstract
摘要

相似文献

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Energy Decomposition-Driven Design of Trop2-Targeting Peptide.基于能量分解的Trop2靶向肽设计
Cell Biochem Biophys. 2025 Aug 8. doi: 10.1007/s12013-025-01866-4.
2
ImmunoPET imaging of Trop2 expression in solid tumors with nanobody tracers.使用纳米抗体示踪剂对实体瘤中Trop2表达进行免疫正电子发射断层显像(ImmunoPET)成像。
Eur J Nucl Med Mol Imaging. 2024 Jan;51(2):380-394. doi: 10.1007/s00259-023-06454-3. Epub 2023 Oct 4.
3
Trop2-targeted immunoPET ligands.靶向Trop2的免疫正电子发射断层显像配体
Am J Nucl Med Mol Imaging. 2025 Jun 25;15(3):105-108. doi: 10.62347/GHKA7738. eCollection 2025.
4
[Preparation of Trop2-Targeted CAR-T Cells Based on Nanobodies and Their Antitumor Effects Against Non-Small Cell Lung Cancer].基于纳米抗体的Trop2靶向嵌合抗原受体T细胞的制备及其对非小细胞肺癌的抗肿瘤作用
Sichuan Da Xue Xue Bao Yi Xue Ban. 2025 Jan 20;56(1):198-205. doi: 10.12182/20250160107.
5
[Tc]Tc-MY6349 Probe for Trop2-Targeted SPECT Imaging: From Preclinical to Pilot Clinical Study.用于靶向Trop2的单光子发射计算机断层显像(SPECT)成像的锝[Tc]Tc-MY6349探针:从临床前研究到初步临床研究
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6
TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer.TROP2 靶向纳米抗体药物偶联物在胰腺癌中产生了强大的抗肿瘤作用。
J Nanobiotechnology. 2023 Nov 6;21(1):410. doi: 10.1186/s12951-023-02183-9.
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Assessment of TROP2, CEACAM5 and DLL3 in metastatic prostate cancer: Expression landscape and molecular correlates.转移性前列腺癌中TROP2、癌胚抗原相关细胞黏附分子5(CEACAM5)和Delta样蛋白3(DLL3)的评估:表达情况及分子关联
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Co-expression of tissue factor, TROP2, and NECTIN4 in primary and matched metastatic cervical cancer lesions.组织因子、TROP2和NECTIN4在原发性及配对转移性宫颈癌病灶中的共表达。
Transl Oncol. 2025 Sep;59:102453. doi: 10.1016/j.tranon.2025.102453. Epub 2025 Jun 26.
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Trophoblast Cell Surface Antigen 2 (Trop2) Is Expressed in Cases of EBV-Positive Diffuse Large B-Cell Lymphoma Emerging from Angioimmunoblastic T-Cell Lymphoma.滋养层细胞表面抗原2(Trop2)在血管免疫母细胞性T细胞淋巴瘤衍生的EBV阳性弥漫性大B细胞淋巴瘤病例中表达。
Reports (MDPI). 2024 May 14;7(2):37. doi: 10.3390/reports7020037.
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[Zr]Zr-DFO-Trodelvy immunoPET for noninvasive Trop2 imaging in bladder cancer.[锆]锆-去铁胺-戈沙妥珠单抗免疫正电子发射断层扫描用于膀胱癌中Trop2的无创成像
Am J Nucl Med Mol Imaging. 2025 Jun 25;15(3):87-96. doi: 10.62347/KKEE6954. eCollection 2025.

本文引用的文献

1
Artificial intelligence in peptide-based drug design.基于肽的药物设计中的人工智能
Drug Discov Today. 2025 Feb;30(2):104300. doi: 10.1016/j.drudis.2025.104300. Epub 2025 Jan 20.
2
Advancements in clinical research and emerging therapies for triple-negative breast cancer treatment.三阴性乳腺癌治疗的临床研究进展与新兴疗法
Eur J Pharmacol. 2025 Feb 5;988:177202. doi: 10.1016/j.ejphar.2024.177202. Epub 2024 Dec 14.
3
Efficacy and safety of sacituzumab govitecan Trop-2-targeted antibody-drug conjugate in solid tumors and UGT1A1*28 polymorphism: a systematic review and meta-analysis.
戈沙妥珠单抗(一种靶向Trop-2的抗体药物偶联物)在实体瘤中的疗效和安全性以及UGT1A1*28基因多态性:一项系统评价和荟萃分析
BJC Rep. 2024 Nov 11;2(1):85. doi: 10.1038/s44276-024-00106-1.
4
Accurate structure prediction of biomolecular interactions with AlphaFold 3.利用 AlphaFold 3 进行生物分子相互作用的精确结构预测。
Nature. 2024 Jun;630(8016):493-500. doi: 10.1038/s41586-024-07487-w. Epub 2024 May 8.
5
A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers.一种新型靶向TROP2的抗体药物偶联物在乳腺癌和肺癌中显示出强大的抗肿瘤疗效。
NPJ Precis Oncol. 2024 Apr 23;8(1):94. doi: 10.1038/s41698-024-00584-z.
6
Peptide-drug conjugates: A new paradigm for targeted cancer therapy.肽药物偶联物:一种针对癌症治疗的新范式。
Eur J Med Chem. 2024 Feb 5;265:116119. doi: 10.1016/j.ejmech.2023.116119. Epub 2024 Jan 1.
7
Neoadjuvant immunotherapy and chemotherapy regimens for the treatment of high-risk, early-stage triple-negative breast cancer: a systematic review and network meta-analysis.新辅助免疫治疗和化疗方案治疗高危早期三阴性乳腺癌:系统评价和网络荟萃分析。
BMC Cancer. 2023 Aug 23;23(1):792. doi: 10.1186/s12885-023-11293-4.
8
Targeting Trop2 by Bruceine D suppresses breast cancer metastasis by blocking Trop2/β-catenin positive feedback loop.靶向 Trop2 的 Bruceine D 通过阻断 Trop2/β-catenin 正反馈环抑制乳腺癌转移。
J Adv Res. 2024 Apr;58:193-210. doi: 10.1016/j.jare.2023.05.012. Epub 2023 Jun 2.
9
Recent advances in the development of therapeutic peptides.治疗性肽的最新进展。
Trends Pharmacol Sci. 2023 Jul;44(7):425-441. doi: 10.1016/j.tips.2023.04.003. Epub 2023 May 27.
10
An assembly of TROP2-mediated signaling events.TROP2介导的信号事件集合。
J Cell Commun Signal. 2023 Sep;17(3):1105-1111. doi: 10.1007/s12079-023-00742-1. Epub 2023 Apr 4.