Jortani S A, Valentour J C, Poklis A
Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0597.
Forensic Sci Int. 1994 Feb;64(2-3):165-70. doi: 10.1016/0379-0738(94)90227-5.
Enantiomers of thioridazine (TRZ) were determined in postmortem tissues obtained from a patient on chronic TRZ therapy by sequential achiral and chiral high pressure liquid chromatography. Tissue concentrations of (+)-TRZ found in liver, brain, bile and blood were: 6.46, 0.40, 0.48 and 0.07 mg/l or mg/kg, respectively. Concentrations of (-)-TRZ in liver, brain, bile and blood were: 12.2, 0.81, 1.07 and 0.20 mg/l or mg/kg, respectively. These data demonstrate the stereoselective disposition of TRZ in human tissues.
通过顺序非手性和手性高效液相色谱法，测定了一名接受慢性硫利达嗪（TRZ）治疗患者死后组织中的硫利达嗪对映体。在肝脏、大脑、胆汁和血液中发现的（+）-TRZ组织浓度分别为：6.46、0.40、0.48和0.07mg/l或mg/kg。肝脏、大脑、胆汁和血液中（-）-TRZ的浓度分别为：12.2、0.81、1.07和0.20mg/l或mg/kg。这些数据证明了TRZ在人体组织中的立体选择性分布。
