Walton James C, Meléndez-Fernández O Hecmarie, DeVries A Courtney, Chantler Paul D, Nelson Randy J
J Vasc Res. 2025 Aug 8:1-11. doi: 10.1159/000547915.
Endogenous biological timing mechanisms are fundamental aspects of living cells, tissues, and organisms. Virtually every aspect of physiology and behavior is mediated by self-sustaining circadian clocks, which depend on light to synchronize with the external daily environment. However, exposure to artificial light at night (ALAN) can impair temporal adaptations, and affect health and disease. During a study of the effects of long-term ALAN exposure on cardiovascular function, we serendipitously detected ultradian rhythms in muscarinic receptor dependent relaxation of isolated aortic tissue. Mice exposed to dark nights displayed an ultradian pattern of maximum endothelial-dependent relaxation that was antiphase between the sexes. Rhythmic patterns of relaxation were abolished by ALAN exposure in both sexes suggesting that ALAN exposure can affect ultradian rhythms in physiology and behavior.
内源性生物计时机制是活细胞、组织和生物体的基本特征。生理学和行为的几乎每个方面都由自我维持的昼夜节律调节，这些节律依赖于光线与外部日常环境同步。然而，夜间暴露于人造光（ALAN）会损害时间适应性，并影响健康和疾病。在一项关于长期ALAN暴露对心血管功能影响的研究中，我们意外地在离体主动脉组织的毒蕈碱受体依赖性舒张中检测到超日节律。暴露于黑暗夜晚的小鼠表现出最大内皮依赖性舒张的超日模式，两性之间呈反相。ALAN暴露消除了两性的舒张节律模式，这表明ALAN暴露会影响生理和行为中的超日节律。
