Dodevska Totka
Department of Organic Chemistry and Inorganic Chemistry, University of Food Technologies, Plovdiv, Bulgaria.
ADMET DMPK. 2025 Jul 18;13(4):2825. doi: 10.5599/admet.2825. eCollection 2025.
Treatment of chronic myeloid leukaemia includes targeted therapy with tyrosine kinase inhibitors (TKIs): imatinib, dasatinib, nilotinib, bosutinib, ponatinib, and asciminib. This review aims to prove that electrochemical sensors provide a reliable alternative to the conventional analytical methods for highly sensitive and cost-effective assay of TKIs in pharmaceutical formulations and biofluids. These platforms have significant advantages in fast detection and portability because they could be designed as miniaturized hand-held devices suitable for real-time point-of-care analysis, providing quick results for enabling personalized therapeutic drug monitoring.
The paper covers recent developments in substrate materials, various electrode designs, the advantages, and limitations of sensors for TKIs, encompassing both basic and applied research.
This is a pioneering study that provides a general review on emerging trends, technologies, and practical applications of electrochemical sensors for TKIs analysis. The article provides researchers with a clear introduction and concise guide to the design and application of electrochemical sensors in the clinical analysis of TKIs.
The review is intended to serve as a valuable resource for researchers in navigating the latest developments in TKIs' electrochemical sensing platforms. The fast response, high sensitivities and satisfactory recoveries obtained in blood serum and urine samples show the potential for application of the proposed electroanalytical systems in clinical analysis and optimization of chemotherapeutic treatments.
慢性髓性白血病的治疗包括使用酪氨酸激酶抑制剂（TKIs）进行靶向治疗，这些抑制剂有伊马替尼、达沙替尼、尼洛替尼、博舒替尼、波纳替尼和阿西替尼。本综述旨在证明，电化学传感器为药物制剂和生物流体中TKIs的高灵敏度和高性价比检测提供了一种可靠的传统分析方法替代方案。这些平台在快速检测和便携性方面具有显著优势，因为它们可以设计成适合实时即时护理分析的小型手持设备，能够快速得出结果以实现个性化治疗药物监测。
本文涵盖了底物材料、各种电极设计、TKIs传感器的优点和局限性等方面的最新进展，包括基础研究和应用研究。
这是一项开创性研究，对TKIs分析电化学传感器的新兴趋势、技术和实际应用进行了全面综述。本文为研究人员提供了关于电化学传感器在TKIs临床分析中的设计和应用的清晰介绍及简明指南。
本综述旨在为研究人员提供宝贵资源，以了解TKIs电化学传感平台的最新进展。在血清和尿液样本中获得的快速响应、高灵敏度和令人满意的回收率表明，所提出的电分析系统在临床分析和化疗治疗优化中具有应用潜力。
