Tontini Gian Eugenio, Spada Cristiano, Uebel Peter, Cannizzaro Renato, Ciprandi Giorgio, Vecchi Maurizio
Department of Pathophysiology and Organ Transplantation University of Milan Milan Italy.
Gastroenterology and Endoscopy Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy.
JGH Open. 2025 Aug 7;9(8):e70237. doi: 10.1002/jgh3.70237. eCollection 2025 Aug.
Bowel preparation for colonoscopy causes significant discomfort to patients. Large volumes, unpleasant taste, and split-dosing are the main disadvantages of most laxatives. Oral mannitol could be an attractive option because it acts quickly, requires low volumes, and has a pleasant taste.
A Phase III study (SATISFACTION) compared oral mannitol with polyethylene glycol-ascorbate (PEG-ADC). This analysis investigated the effects on patient-reported outcomes (PROMs), mainly concerning the perception of using the preparations.
The SATISFACTION Phase III study was an international, multicenter, randomized (1:1), parallel-group, endoscopist-blinded, non-inferiority trial. Taste of preparations, ease of use, and willingness to repeat the preparation with the same product were scored and assessed by the patients.
Bowel preparation with oral mannitol resulted in a better patient satisfaction profile for all PROMs evaluated.
Oral mannitol for bowel preparation achieved high patient satisfaction and might be a valuable option for colonoscopy.
ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT04759885).
结肠镜检查的肠道准备会给患者带来极大不适。大多数泻药的主要缺点是用量大、味道不佳和分剂量服用。口服甘露醇可能是一个有吸引力的选择，因为它起效快、用量少且味道宜人。
一项III期研究（满意度研究）比较了口服甘露醇与聚乙二醇 - 抗坏血酸盐（PEG - ADC）。该分析调查了对患者报告结局（PROMs）的影响，主要涉及对使用这些制剂的感受。
满意度III期研究是一项国际多中心、随机（1:1）、平行组、内镜医师盲法、非劣效性试验。患者对制剂的味道、易用性以及是否愿意使用同一产品重复进行肠道准备进行评分和评估。
对于所有评估的患者报告结局，口服甘露醇进行肠道准备的患者满意度更高。
口服甘露醇进行肠道准备获得了较高的患者满意度，可能是结肠镜检查的一个有价值的选择。
ClinicalTrials.gov（https://clinicaltrials.gov/ct2/show/NCT04759885）。
