Thomas Merlin, Hussein Mousa, Al Rashid Amal, Mohamed Maysa, Kambal Aalaa, Kumar Rajendra, Ali Hameed Mansoor, Singh Rajvir, Ahmad Mushtaq, George Saibu, Akram Jaweria, Al Adab Aisha Hussain O, Rajagopal Rajalekshmi Maheswari, Sharma Rohit, Raza Tasleem
Department of Chest, Hamad General Hospital, Doha, Qatar.
Department of Clinical Medicine, Weill Cornell Medicine-Qatar, Ar-Rayyan, Qatar.
Qatar Med J. 2025 Jun 30;2025(2):40. doi: 10.5339/qmj.2025.40. eCollection 2025.
We aimed to determine the radiological changes on computed tomography (CT) scans of the chest and pulmonary function abnormalities at a 1-year follow-up in intensive care unit (ICU) survivors with severe COVID-19.
A 2-year prospective cohort study with an enrollment of 204 patients within 3 months after their discharge from the ICU at Hamad General Hospital, the tertiary care center in Qatar.
The mean age of our cohort was 48.7 ± 8.6 years. CT chest was performed on a total of 135 patients at a 1-year follow-up, out of which 43 patients had a CT chest during hospital admission with COVID-19. Abnormal CT chest findings were seen in 118 (87.4%) patients at 1 year. The mean CT severity score significantly improved at 1 year (8.1 ± 6.8 vs. 19.4 ± 3.6, < 0.001). Those with an abnormal CT chest in 1 year had a significantly lower but normal predicted forced vital capacity (91.9% ± 15.4 vs. 81.1% ± 13.7, = 0.01), predicted total lung capacity (82.5% ± 13.9 vs. 94.3% ± 12.7, = 0.02) and oxygen saturation after 6-minute walk test (6MWT) (97.5 ± 1.2 vs. 98.3 ± 0.651, = 0.033). 6MWT distance was significantly shorter than the predicted distance in those with an abnormal CT (63 (62.4%) vs. 7 (77.8%), = 0.020).
Patients recovering from severe COVID-19 have significant improvement but persistent radiological changes at a 1-year follow-up that correlate with several physiological parameters, but these findings are limited by the absence of pre-COVID-19 baseline imaging.
我们旨在确定重症新型冠状病毒肺炎（COVID-19）的重症监护病房（ICU）幸存者在1年随访时胸部计算机断层扫描（CT）的影像学变化及肺功能异常情况。
一项为期2年的前瞻性队列研究，在卡塔尔三级护理中心哈马德总医院ICU出院后3个月内纳入204例患者。
我们队列的平均年龄为48.7±8.6岁。在1年随访时，共对135例患者进行了胸部CT检查，其中43例患者在COVID-19住院期间进行过胸部CT检查。1年时，118例（87.4%）患者出现胸部CT异常表现。1年时CT严重程度评分显著改善（8.1±6.8对19.4±3.6，<0.001）。1年时胸部CT异常的患者其预测用力肺活量显著降低但仍正常（91.9%±15.4对81.1%±13.7，=0.01），预测肺总量（82.5%±13.9对94.3%±12.7，=0.02）以及6分钟步行试验（6MWT）后的血氧饱和度（97.5±1.2对98.3±0.651，=0.033）。6MWT距离在胸部CT异常的患者中显著短于预测距离（63例（62.4%）对7例（77.8%），=0.020）。
从重症COVID-19康复的患者在1年随访时有显著改善，但仍存在持续的影像学变化，这些变化与多个生理参数相关，但由于缺乏COVID-19前的基线影像学检查，这些发现存在局限性。
