Zhunussova Alina, Loane Clare, Kurt Elif, Femminella Grazia Daniela, Lenzoni Sabrina, Duckett Millie, Callaghan Martina F, Weiskopf Nikolaus, Dolan Raymond J, Howard Robert, Düzel Emrah, Hämmerer Dorothea
Department of Psychology, University of Innsbruck, Universitätsstraße 5-7, 6020 Innsbruck, Austria.
Institute of Cognitive Neuroscience, University College London, Alexandra House, 17-19 Queen Square, London WC1N 3AZ, United Kingdom.
bioRxiv. 2025 Jul 18:2025.07.18.663475. doi: 10.1101/2025.07.18.663475.
Pupil dilation (PD) can be easily measured and reflects responses to subjectively salient or cognitively demanding events. It therefore holds promise as a cognitive marker especially for individuals with mild cognitive impairment (MCI) or other neurodegenerative conditions with restricted abilities to respond in cognitive assessments. We assessed PD during two tasks, an oddball task for investigating attentional allocation and a Simon task which additionally allows for investigating cognitive effort in younger adults (YAs), older adults (OAs), and patients with MCI. PD is a useful marker for investigating attention and cognitive effort in MCI, as suggested by elevated PD to salient stimuli in particular of individuals with better attentional control in MCI patients, as well as YAs and OAs. Measurement of PD may serve as an easy-to-administer measure to assess changes in cognitive function in healthy aging and MCI.
瞳孔扩张（PD）易于测量，且能反映对主观显著或认知要求较高事件的反应。因此，它有望成为一种认知标志物，尤其适用于轻度认知障碍（MCI）患者或其他在认知评估中反应能力受限的神经退行性疾病患者。我们在两项任务中评估了PD，一项用于研究注意力分配的oddball任务，以及一项额外用于研究年轻人（YAs）、老年人（OAs）和MCI患者认知努力的西蒙任务。正如MCI患者以及年轻人和老年人中对显著刺激的瞳孔扩张升高所表明的那样，PD是研究MCI患者注意力和认知努力的有用标志物。PD测量可作为一种易于实施的方法，用于评估健康衰老和MCI患者认知功能的变化。
