Bautista-Robles Verónica, Keita Hady, Gamero Edgar Julián Paredes, Leite Layna Tayná Brito, Muller Jessica de Araújo Isaías, Kadri Mônica Cristina Toffoli, Lafourcade Prada Ariadna, Amado Jesús Rafael Rodríguez
College of Pharmaceutical Sciences, Food and Nutrition. Federal University of Mato Grosso do Sul, Av. Costa e Silva s/n, 79070-900, Campo Grande-MS, Brazil.
Postgraduate Studies Division, University of Sierra Sur, Guillermo Rojas Mijangos s/n, 70800 Miahuatlán de Porfirio Díaz, Oaxaca, México.
Beilstein J Nanotechnol. 2025 Aug 6;16:1277-1288. doi: 10.3762/bjnano.16.93. eCollection 2025.
The oil from the pulp of the bocaiúva fruit may have several medical applications. However, little is known about its pharmacological activity. Therefore, this study aimed to develop and evaluate the anti-inflammatory activity of a nanoemulsion loaded with the oil extracted from the pulp of the fruit of . Griffin's method determined the hydrophilic-lipophilic equilibrium ratio of the nanoemulsion. It was shown to have an adequate droplet size (173.60 nm) with excellent homogeneity (polydispersity index 0.200). The anti-inflammatory activity of the nanoemulsion was evaluated by the carrageenan-induced paw edema method. Finally, the non-hemolytic and cytotoxic activity of the nanoformulation was determined to assess its safety. The nanoemulsion loaded with fruit pulp oil was shown to have parameters suitable for its characterization, impressive anti-inflammatory activity, and a safe profile.
博卡尤瓦果实果肉中的油可能有多种医学应用。然而，对其药理活性了解甚少。因此，本研究旨在开发并评估一种负载从该果实果肉中提取的油的纳米乳剂的抗炎活性。采用格里芬法测定纳米乳剂的亲水亲油平衡比。结果表明其具有合适的液滴尺寸（173.60纳米）和优异的均匀性（多分散指数0.200）。通过角叉菜胶诱导的爪肿胀法评估纳米乳剂的抗炎活性。最后，测定纳米制剂的非溶血和细胞毒性活性以评估其安全性。负载该果实果肉油的纳米乳剂显示出适合其表征的参数、令人印象深刻的抗炎活性和安全特性。
