非小细胞肺癌患者放化疗期间肠道微生物群的稳定性及其与放射性肺炎的关联
Stability of gut microbiota in non-small cell lung cancer patients during chemoradiotherapy and its association with radiation pneumonitis.
作者信息
Xi Yu, Liu FangJie, Dong YaoLing, Wang Zhi, Zhao Qi, Li XiaoXing, Zhang PengXin, Zheng ShiYang, Zhou Rui, Wu QingPing, Liu Hui, Qiu Bo
机构信息
National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China.
Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
出版信息
iScience. 2025 Jul 19;28(8):113163. doi: 10.1016/j.isci.2025.113163. eCollection 2025 Aug 15.
To assess the intra-patient stability of gut microbiota across longitudinal samples in non-small cell lung cancer (NSCLC) patients treated with chemoradiotherapy (CCRT), its association with radiation pneumonitis (RP), and the factors driving such stability. Intra-patient gut microbial stability between consecutive time points was quantified by stability coefficients (mS scores) using iteratively growing-partitioned clustering. Patients with G0 RP exhibited higher mS scores compared with those with G2+ RP. LEfSe analysis of probiotic microbes revealed enrichment of ( = 0.030) and ( = 0.045) in the high-stability group. The baseline abundance of ( = 0.040) was identified as an independent predictor of microbial stability during CCRT. Higher gut microbiota stability was associated with lower risk of RP in NSCLC. The composition of probiotics may contribute to the preservation of gut microbiota stability, and serve as a potential target to mitigate RP.
为评估接受放化疗（CCRT）的非小细胞肺癌（NSCLC）患者纵向样本中肠道微生物群的患者内稳定性、其与放射性肺炎（RP）的关联以及驱动这种稳定性的因素。使用迭代生长分区聚类通过稳定性系数（mS评分）对连续时间点之间的患者内肠道微生物稳定性进行量化。与G2 + RP患者相比，G0 RP患者表现出更高的mS评分。益生菌微生物的LEfSe分析显示，高稳定性组中（ = 0.030）和（ = 0.045）富集。（ = 0.040）的基线丰度被确定为CCRT期间微生物稳定性的独立预测因子。较高的肠道微生物群稳定性与NSCLC患者较低的RP风险相关。益生菌的组成可能有助于维持肠道微生物群的稳定性，并作为减轻RP的潜在靶点。
Zotero 插件