使用各种储存介质对脱位牙牙周膜细胞活力的评估：一项系统评价和荟萃分析。
The evaluation of periodontal ligament cell viability for an avulsed tooth using various storage media: A systematic review and meta-analysis.
作者信息
Gayan Anushka, Chaitra T R, Chaudhary Seema, Ravishankar T L, Sudan Supinder, Bezborah Bornisha
机构信息
Department of Paediatric and Preventive Dentistry, India.
Department of Paediatric and Preventive Dentistry, Kothiwal Dental College and Research Center, Moradabad, India.
出版信息
J Oral Biol Craniofac Res. 2025 Sep-Oct;15(5):1157-1161. doi: 10.1016/j.jobcr.2025.07.020. Epub 2025 Jul 31.
BACKGROUND
Many storage mediums are available for the storage of avulsed teeth to preserve the viability of periodontal ligament (PDL) cells before replantation; however, it is unclear which medium is the optimal option
AIM
This systematic review and meta-analysis (MA) aimed to evaluate the effectiveness of various storage media in preserving the viability of periodontal ligament (PDL) cells, using Hank's Balanced Salt Solution (HBSS) as a reference standard for comparison.
REVIEW METHOD
This systematic review was performed according to PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. The database including Medline (via. PUBMED), Scopus, The Cochrane Controlled Clinical trials Register, Google scholar were thoroughly searched from 2014 to 2024. The reference articles which have been retrived were exported to Mendeley Desktop software 1.13.3.43.
RESULT
HBSS medium did not show significant difference in cell viability when compared with placentrix (Mean difference: 0.56, 95 % CI(-5.64,-0.04), p = 0.05, I2 = 96 %), whereas aloevera showed superior cell viability compared to HBSS. : This systematic review and MA suggests that placentrex and aloevera could represent an alternative to HBSS. However, more studies are necessary to obtain a reliable conclusion.
背景
有多种储存介质可用于储存脱位牙，以在再植前保持牙周膜（PDL）细胞的活力；然而，尚不清楚哪种介质是最佳选择。
目的
本系统评价和荟萃分析（MA）旨在以汉克平衡盐溶液（HBSS）作为比较的参考标准，评估各种储存介质在保存牙周膜（PDL）细胞活力方面的有效性。
综述方法
本系统评价按照PRISMA（系统评价和荟萃分析的首选报告项目）指南进行。对2014年至2024年期间的数据库进行了全面检索，包括Medline（通过PUBMED）、Scopus、Cochrane对照临床试验注册库、谷歌学术。将检索到的参考文献导出到Mendeley Desktop软件1.13.3.43中。
结果
与胎盘提取物相比，HBSS培养基在细胞活力方面未显示出显著差异（平均差异：0.56，95%CI（-5.64，-0.04），p = 0.05，I² = 96%），而芦荟与HBSS相比显示出更高的细胞活力。本系统评价和荟萃分析表明，胎盘提取物和芦荟可以作为HBSS的替代品。然而，需要更多的研究来得出可靠的结论。
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