Pandey Varun, Shahi Preeti, Kolios George, Uddin Muhammad Ikhtear, Spathakis Michail, Collins Alexandra R, Paspaliaris Vasilis, Rai Ambak Kumar
Paspa Pharmaceuticals Pty Ltd., 875 Glen Huntly Road, Caulfield, VIC, 3162, Australia.
Syngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra Jigani Link Road, Bangalore, 560 099, India.
Infection. 2025 Aug 12. doi: 10.1007/s15010-025-02626-5.
Human metapneumovirus (hMPV) is a significant cause of respiratory infections worldwide, particularly in young children, the elderly, and immunocompromised individuals. Since its discovery in 2001, hMPV has been recognized as a major contributor to acute respiratory tract infections, along with respiratory syncytial virus (RSV) and influenza. This review explores the virology, epidemiology, pathogenesis, clinical manifestations, diagnostic methods, and recent advances in therapeutic and preventive strategies for hMPV infection. By consolidating current knowledge, we aim to highlight the importance of hMPV in public health and the need for continued research to address its clinical and economic burdens.
人偏肺病毒（hMPV）是全球范围内呼吸道感染的重要病因，尤其是在幼儿、老年人和免疫功能低下的个体中。自2001年被发现以来，hMPV已被公认为是急性呼吸道感染的主要病原体之一，与呼吸道合胞病毒（RSV）和流感病毒一样。本综述探讨了hMPV感染的病毒学、流行病学、发病机制、临床表现、诊断方法以及治疗和预防策略的最新进展。通过整合现有知识，我们旨在强调hMPV在公共卫生中的重要性以及持续开展研究以应对其临床和经济负担的必要性。
