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臭氧联合丹参注射液及麒麟丸介入输卵管再通术对输卵管阻塞性不孕症的影响

Effects of interventional fallopian tube recanalization with ozone combined with Salvia miltiorrhiza injection and Qilin pill on tubal obstructive infertility.

作者信息

Zheng Shilin, Wu Yun, Jiang Shengpan, Tan Yiqing

机构信息

Department of Interventional Medicine, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, Hubei Province, China.

Radiology Department, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, Hubei Province, China.

出版信息

Medicine (Baltimore). 2025 Aug 8;104(32):e43863. doi: 10.1097/MD.0000000000043863.

Abstract

Fallopian tube obstruction is a common etiological factor contributing to female infertility. Interventional fallopian tube recanalization with ozone (FTRO) has emerged as a therapeutically efficacious treatment modality for resolving tubal obstructive infertility. However, the efficacy of this approach is limited by the incidence of readhesion of the fallopian tubes. Incorporating Salvia miltiorrhiza and Qilin pill into FTRO treatment holds the potential to effectively prevent re-obstruction of the fallopian tubes. Nonetheless, there is currently a lack of robust studies evaluating the efficacy of this combined therapeutic approach. We conducted a retrospective analysis involving 300 patients with fallopian tube obstruction who underwent treatment at our hospital from March 2015 to September 2021. The treatment approach utilized was interventional FTRO, combined with adjunctive therapies. Based on the treatment method employed, the patients were categorized into 3 groups: group A underwent interventional FTRO only; group B received interventional FTRO combined with S miltiorrhiza injection into the fallopian tube cavity; and group C received interventional FTRO combined with S miltiorrhiza injection into the fallopian tube cavity, followed by Qilin pill administration. After the treatment, there was a significant improvement in hormone levels across all groups, with group C showing the most notable improvement and the lowest incidence of treatment-related complications compared to the other groups (P < .05). The combined approach of interventional FTRO, S miltiorrhiza injection, and Qilin pill is highly therapeutically efficacious for patients with infertility caused by fallopian tube obstruction.

摘要

输卵管阻塞是导致女性不孕的常见病因。臭氧介入输卵管再通术(FTRO)已成为解决输卵管阻塞性不孕的一种有效治疗方式。然而,这种方法的疗效受到输卵管再粘连发生率的限制。将丹参和麒麟丸纳入FTRO治疗有可能有效预防输卵管再次阻塞。尽管如此,目前缺乏有力的研究来评估这种联合治疗方法的疗效。我们对2015年3月至2021年9月在我院接受治疗的300例输卵管阻塞患者进行了回顾性分析。采用的治疗方法是介入性FTRO,并辅以其他治疗。根据所采用的治疗方法,将患者分为3组:A组仅接受介入性FTRO;B组接受介入性FTRO并联合输卵管腔内注射丹参;C组接受介入性FTRO并联合输卵管腔内注射丹参,随后服用麒麟丸。治疗后,所有组的激素水平均有显著改善,与其他组相比,C组改善最为显著,治疗相关并发症的发生率最低(P<0.05)。介入性FTRO、丹参注射和麒麟丸的联合方法对输卵管阻塞所致不孕患者具有很高的治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/12338143/30b2f1f085fe/medi-104-e43863-g001.jpg

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