Liang Lei, Li Lan, Wang Dexin, Zhang Xiubi, Zhang Xiaohe, Tian Gang, Yue Chaochi, Du Weiliang
College of Integrative Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan Province, China.
Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Molecular Diagnosis of Clinitional Chinese Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China.
Medicine (Baltimore). 2025 Aug 8;104(32):e43854. doi: 10.1097/MD.0000000000043854.
Perianal fistula is a frequent and severe complication of Crohn disease (CD). With the rising incidence of perianal fistulas in CD (pfCD), research activity in this field has grown substantially. Although several reviews have addressed CD and pfCD, comprehensive analyses summarizing research trends and hotspots in pfCD remain limited.
Relevant articles and reviews were retrieved from the Web of Science Core Collection database. Citespace (version 6.3.1), Scimago Graphica (version 1.0.42), and VOSviewer (version 1.6.15) were used to systematically analyze data on publications, countries, institutions, authors, and keywords.
Visual analysis of 692 articles on pfCD from 2004 to 2024 revealed evolving trends and research foci in the field. From 2004 to 2015, annual publication output remained relatively stable; however, it increased markedly thereafter, reaching 65 articles in 2024. Institutions from Europe and North America have contributed substantially to the field. Recent studies have focused on mesenchymal stem cells therapy, anti-tumor necrosis factor treatment, surgical interventions, diagnostic strategies, and therapeutic outcomes.
This bibliometric analysis provides a comprehensive overview of developmental trends and emerging hotspots in pfCD research, offering valuable insights for future investigations.
肛周瘘是克罗恩病（CD）常见且严重的并发症。随着CD患者肛周瘘（pfCD）发病率的上升，该领域的研究活动大幅增加。尽管已有多篇综述探讨了CD和pfCD，但对pfCD研究趋势和热点进行全面分析的综述仍然有限。
从科学网核心合集数据库中检索相关文章和综述。使用Citespace（6.3.1版）、Scimago Graphica（1.0.42版）和VOSviewer（1.6.15版）对出版物、国家、机构、作者和关键词的数据进行系统分析。
对2004年至2024年692篇关于pfCD的文章进行可视化分析，揭示了该领域不断变化的趋势和研究重点。2004年至2015年，年发表量相对稳定；然而，此后显著增加，2024年达到65篇。欧洲和北美的机构对该领域贡献巨大。近期研究集中在间充质干细胞治疗、抗肿瘤坏死因子治疗、手术干预、诊断策略和治疗结果。
这项文献计量分析全面概述了pfCD研究的发展趋势和新出现的热点，为未来研究提供了有价值的见解。
