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病例报告:克罗恩病合并肠系膜神经鞘瘤。

Case Report: Crohn's disease with coexisting mesenteric schwannoma.

作者信息

Lu Juntao, Qiao Yuqi, Wang Tianrong, Cao Zhijun

机构信息

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.

出版信息

Front Med (Lausanne). 2025 Jul 29;12:1621976. doi: 10.3389/fmed.2025.1621976. eCollection 2025.

DOI:10.3389/fmed.2025.1621976
PMID:40800145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12339563/
Abstract

This case report discusses a rare instance of Crohn's disease coexisting with a mesenteric schwannoma in a 22-year-old man. The patient initially presented with painful defecation and recurrent fever. Diagnostic procedures, including MRI, CTE, and FDG-PET/CT, revealed signs consistent with Crohn's disease and an enlarged abdominal "lymph node" suspected to be a schwannoma. Despite exclusive enteral nutrition, the nodule persisted, complicating further treatment. Surgical resection confirmed the diagnosis of schwannoma. This report highlights the diagnostic challenges and treatment complexities when Crohn's disease coexists with rare tumors such as schwannomas.

摘要

本病例报告讨论了一名22岁男性克罗恩病与肠系膜神经鞘瘤共存的罕见病例。患者最初表现为排便疼痛和反复发热。包括MRI、CTE和FDG-PET/CT在内的诊断程序显示出与克罗恩病相符的体征以及一个疑似神经鞘瘤的腹部“淋巴结”肿大。尽管采用了全肠内营养,该结节仍然存在,使进一步治疗变得复杂。手术切除证实为神经鞘瘤。本报告强调了克罗恩病与神经鞘瘤等罕见肿瘤共存时的诊断挑战和治疗复杂性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d207/12339563/85b8cdd8f29d/fmed-12-1621976-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d207/12339563/048dd4a54dfb/fmed-12-1621976-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d207/12339563/59a149656f2d/fmed-12-1621976-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d207/12339563/85b8cdd8f29d/fmed-12-1621976-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d207/12339563/048dd4a54dfb/fmed-12-1621976-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d207/12339563/59a149656f2d/fmed-12-1621976-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d207/12339563/85b8cdd8f29d/fmed-12-1621976-g003.jpg

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Case Report: Crohn's disease with coexisting mesenteric schwannoma.病例报告:克罗恩病合并肠系膜神经鞘瘤。
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本文引用的文献

1
Mesenteric Schwannoma, Intestinal Malrotation and Ileal Diverticulum: A Unique Association.肠系膜神经鞘瘤、肠旋转不良和回肠憩室:一种独特的关联。
Acta Med Port. 2023 Apr 3;36(4):278-282. doi: 10.20344/amp.17544. Epub 2022 Aug 1.
2
Colonic schwannoma: A case of unusual presentation and outcome.结肠神经鞘瘤:一例表现异常及预后情况
Rare Tumors. 2022 Jun 24;14:20363613221110837. doi: 10.1177/20363613221110837. eCollection 2022.
3
Schwannoma in and around the porta hepatis: radiological features in eight cases and literature review.
肝门区及其周围的神经鞘瘤:8例放射学特征及文献复习
Abdom Radiol (NY). 2022 Jun;47(6):1917-1928. doi: 10.1007/s00261-022-03524-2. Epub 2022 Apr 30.
4
[A case of primary mesenteric schwannoma with secondary ossification].[一例伴继发性骨化的原发性肠系膜神经鞘瘤]
Nihon Shokakibyo Gakkai Zasshi. 2022;119(1):53-60. doi: 10.11405/nisshoshi.119.53.
5
Chronic abdominal pain due to mesenteric schwannoma.肠系膜神经鞘瘤导致的慢性腹痛。
Rev Esp Enferm Dig. 2020 Sep;112(9):738. doi: 10.17235/reed.2020.6876/2020.
6
Peritumoral lymphoid cuff correlates well with lymph node enlargement in gastrointestinal schwannomas.胃肠道神经鞘瘤的瘤周淋巴样套与淋巴结肿大密切相关。
Oncotarget. 2018 Feb 9;9(16):12591-12598. doi: 10.18632/oncotarget.24476. eCollection 2018 Feb 27.
7
Successful treatment of a giant ossified benign mesenteric schwannoma.成功治疗巨大骨化良性肠系膜施万细胞瘤。
World J Gastroenterol. 2018 Jan 14;24(2):303-309. doi: 10.3748/wjg.v24.i2.303.
8
Appendiceal schwannoma: an incidental finding after Crohn's bowel resection.
ANZ J Surg. 2019 Jan;89(1-2):E35-E36. doi: 10.1111/ans.13966. Epub 2017 Mar 20.
9
Bowel mesentery (meso-appendix) microcystic/reticular schwannoma: case report and literature review.肠系膜(阑尾系膜)微囊性/网状神经鞘瘤:病例报告及文献复习
World J Gastroenterol. 2014 Feb 7;20(5):1371-6. doi: 10.3748/wjg.v20.i5.1371.
10
Asymptomatic Ileal Schwannoma presenting as a Mesenteric Tumour: Case report and review of literature.表现为肠系膜肿瘤的无症状回肠神经鞘瘤:病例报告及文献复习
Sultan Qaboos Univ Med J. 2013 May;13(2):E330-3. doi: 10.12816/0003247. Epub 2013 May 9.