Hubbard B M, Anderson J M
Neuropathol Appl Neurobiol. 1985 Sep-Oct;11(5):369-82. doi: 10.1111/j.1365-2990.1985.tb00033.x.
The cell content of the cerebral cortex in senile dementia of Alzheimer type has been examined using a stereological method which combines gross cortical measurements and microscopical observations to give volumetric data on cells and neuropil. In the neocortex only the large (greater than 12 micron diameter) neuron fraction was found to be abnormal; the volume of these cells was reduced in most patients aged less than 80 years, but was not usually abnormal for age in older cases. Smaller neurons and glial cells showed no consistent change from normal values. Neuropil was diminished in both age groups, so that patients over 80 years of age tended to show cerebral atrophy without neocortical neuron loss. By contrast to the neocortex, the subiculum of the hippocampus consistently showed pathological neuron loss in both age groups.
采用一种体视学方法对阿尔茨海默型老年痴呆症患者大脑皮质的细胞成分进行了检查，该方法结合了大体皮质测量和显微镜观察，以提供细胞和神经毡的体积数据。在新皮质中，仅发现大（直径大于12微米）神经元部分异常；在大多数年龄小于80岁的患者中，这些细胞的体积减小，但在老年病例中，其体积通常并无随年龄增长而出现的异常。较小的神经元和神经胶质细胞与正常值相比未显示出一致的变化。两个年龄组的神经毡均减少，因此80岁以上的患者往往表现为脑萎缩但无新皮质神经元丢失。与新皮质相反，海马体下托在两个年龄组中均持续出现病理性神经元丢失。
