Wu Jiake, Cai Yang, Lu Bei, Xu Yanan, Zhuo Jianyong, Yin Junjie
Department of clinical medicine, Zhejiang Chinese Medical University, China.
Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, School of medicine, Westlake university, China.
J Int Med Res. 2025 Aug;53(8):3000605251365855. doi: 10.1177/03000605251365855. Epub 2025 Aug 13.
Large cell neuroendocrine carcinoma of the lung is a rare and aggressive malignancy with a high propensity for metastasis. This carcinoma demonstrates a significantly higher propensity for hepatic metastasis compared with other non-small cell lung cancer subtypes, thereby exacerbating therapeutic complexity and worsening prognosis. A man in his early 60s was admitted to our institution with a hepatic space-occupying lesion. Hepatic segmentectomy was performed, and histopathological examination confirmed a neuroendocrine carcinoma. Following stabilization of vital signs, the patient underwent uniportal video-assisted thoracoscopic surgery for partial lobectomy of the right upper lung. Subsequent histopathological analysis confirmed the diagnosis of hepatic metastasis originating from pulmonary large cell neuroendocrine carcinoma. This case highlights that clinicians should maintain a high index of suspicion for large cell neuroendocrine carcinoma when encountering multifocal malignancies.
肺大细胞神经内分泌癌是一种罕见且侵袭性强的恶性肿瘤，具有较高的转移倾向。与其他非小细胞肺癌亚型相比，这种癌表现出明显更高的肝转移倾向，从而加剧了治疗的复杂性并恶化了预后。一名60岁出头的男性因肝脏占位性病变入住我院。进行了肝段切除术，组织病理学检查证实为神经内分泌癌。生命体征稳定后，患者接受了单孔电视辅助胸腔镜手术，进行右上肺部分肺叶切除术。随后的组织病理学分析证实诊断为源自肺大细胞神经内分泌癌的肝转移。该病例强调，临床医生在遇到多灶性恶性肿瘤时，应高度怀疑大细胞神经内分泌癌。
