通过使用乳糖作为冻干介质提高脑膜炎球菌多糖疫苗的稳定性。
Enhanced stability of meningococcal polysaccharide vaccines by using lactose as a menstruum for lyophilization.
作者信息
Tiesjema R H, Beuvery E C, te Pas B J
出版信息
Bull World Health Organ. 1977;55(1):43-8.
Abstract
A comparison is made between lactose and mannitol as additives for the lyophilization of meningococcal polysaccharide vaccines. From the stability data obtained on storage at high temperatures, it is concluded that vaccines containing lactose as a menstruum for lyophilization are much more stable than vaccines prepared with the currently used additive, mannitol. The enhanced stability of these vaccines makes it possible to store also group A vaccines at 5 degrees C instead of at -20 degrees C, and to use them in places without freezing facilities.
摘要
对乳糖和甘露醇作为脑膜炎球菌多糖疫苗冻干添加剂进行了比较。从高温储存获得的稳定性数据得出结论，含有乳糖作为冻干溶媒的疫苗比用目前使用的添加剂甘露醇制备的疫苗稳定得多。这些疫苗稳定性的提高使得A群疫苗也可以在5摄氏度而不是-20摄氏度下储存，并可在没有冷冻设施的地方使用。
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