Kheradmand Motahareh, Ranjbaran Hossein, Alizadeh-Navaei Reza, Yakhkeshi Reza, Moosazadeh Mahmood
Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Immunogenetic Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Int J Prev Med. 2021 Sep 29;12:121. doi: 10.4103/ijpvm.IJPVM_336_19. eCollection 2021.
White Blood Cells (WBC) can be a useful marker to predict diabetes. In this study, we aimed to investigate the association between WBC count with type 2 diabetes in a large-scaled population-based cohort study.
In the present study we used a subset of data collected in enrolment phase of Tabari cohort study. Participants with fasting blood glucose ≥126 or those who report as having diabetes or taking glucose-lowering medications were selected as case group (1765 participants) and control group included participants who did not report as having diabetes (1765 participants) and they randomly selected from the baseline population. Hematology indices were measured for all participants using Celltac Alpha MEK-6510 K. Chi-squared and independent t-test were used to compare categorical and continuous variables, respectively.
The mean of WBC in diabetic patients and control group was 6.89 ± 1.67 and 6.37 ± 1.49 respectively ( ≤ 0.001). The odds of diabetes based on WBC count in crud model was 1.23 [CI 95% 1.181.28] and after adjustment for all possible confounding factor was 1.17 [CI 95% 1.111.23].
Results of the present study showed a significant association between WBC count and diabetes. This association remained significant after adjustment for all possible confounders.
白细胞（WBC）可能是预测糖尿病的一个有用标志物。在本研究中，我们旨在通过一项大规模的基于人群的队列研究，调查白细胞计数与2型糖尿病之间的关联。
在本研究中，我们使用了塔巴里队列研究入组阶段收集的数据子集。空腹血糖≥126的参与者，或报告患有糖尿病或正在服用降糖药物的参与者被选为病例组（1765名参与者），对照组包括未报告患有糖尿病的参与者（1765名参与者），他们是从基线人群中随机选取的。使用Celltac Alpha MEK-6510 K为所有参与者测量血液学指标。分别使用卡方检验和独立t检验来比较分类变量和连续变量。
糖尿病患者组和对照组的白细胞平均计数分别为6.89±1.67和6.37±1.49（≤0.001）。在粗模型中，基于白细胞计数的糖尿病比值比为1.23[95%置信区间1.18 - 1.28]，在对所有可能的混杂因素进行调整后为1.17[95%置信区间1.11 - 1.23]。
本研究结果表明白细胞计数与糖尿病之间存在显著关联。在对所有可能的混杂因素进行调整后，这种关联仍然显著。
