Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, No. 139, Renmin Rd, Changsha, 410011, China.
Department of Metabolism and Endocrinology, The Third Hospital of Changsha, 176, West Labour Road, Changsha, 410011, China.
Rev Endocr Metab Disord. 2022 Jun;23(3):569-577. doi: 10.1007/s11154-021-09704-7. Epub 2022 Jan 27.
Galectin-3 is a member of the galectin family, widely expressed in immune cells and plays a role mainly in inflammation, autoimmunity, apoptosis, and chemotaxis. We summarized the roles of Galectin-3 in diabetes and its complications, as well as the underlying mechanisms. Clinical research has determined that the circulating level of Galectin-3 is closely related to diabetes and its complications, thus it is promising to use Galectin-3 as a predictor and biomarker for those diseases. Galectin-3 also may be considered as an ideal therapeutic target, which has broad prospects in the prevention and treatment of diabetes and its complications, especially macrovascular and microvascular complications.
半乳糖凝集素-3 是半乳糖凝集素家族的一员，广泛表达于免疫细胞中，主要在炎症、自身免疫、细胞凋亡和趋化作用中发挥作用。我们总结了半乳糖凝集素-3 在糖尿病及其并发症中的作用及其潜在机制。临床研究已经确定，循环中的半乳糖凝集素-3 水平与糖尿病及其并发症密切相关，因此有望将半乳糖凝集素-3 用作这些疾病的预测因子和生物标志物。半乳糖凝集素-3 也可能被视为一个理想的治疗靶点，在糖尿病及其并发症，特别是大血管和微血管并发症的防治方面具有广阔的前景。
