Bast Julia A, Olubi Olubunkola, Le D Elizabeth, Parashar Susmita, Dobrescu Ioana, Kondapalli Lavanya
Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Division of Cardiology, Piedmont Heart Institute, Fayetteville, GA, USA.
Curr Cardiol Rep. 2025 Aug 13;27(1):126. doi: 10.1007/s11886-025-02265-0.
To provide a comprehensive review of cardiovascular risks associated with premature menopause.
Premature menopause, defined as permanent cessation of menstruation before the age of 40, is associated with an increased risk of developing cardiovascular disease. A variety of disease states and treatment exposures can lead to premature menopause resulting in a growing population of women at risk for the development of cardiovascular disease. This review summarizes current data substantiating the adverse cardiovascular outcomes seen in premature ovarian insufficiency, surgical menopause, polycystic ovarian syndrome, and cancer treatment-induced menopause. Premature menopause significantly increases the risk of long-term cardiovascular events. Multidisciplinary healthcare models that emphasize screening women with premature menopause for cardiovascular risk factors are essential to improving the cardiovascular health and longevity of this vulnerable population.
全面综述与过早绝经相关的心血管风险。
过早绝经定义为40岁前月经永久性停止，与患心血管疾病风险增加相关。多种疾病状态和治疗暴露可导致过早绝经，从而使面临心血管疾病发生风险的女性群体不断增加。本综述总结了当前数据，证实了在早发性卵巢功能不全、手术绝经、多囊卵巢综合征和癌症治疗所致绝经中观察到的不良心血管结局。过早绝经显著增加长期心血管事件风险。强调对过早绝经女性进行心血管危险因素筛查的多学科医疗模式对于改善这一弱势群体的心血管健康和寿命至关重要。
