• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于声学显微镜和红外光谱映射成像的早期原位黑色素瘤诊断系统

Diagnostic System for Early In Situ Melanoma Detection Using Acoustic Microscopy and Infrared Spectroscopic Mapping Imaging.

作者信息

Karagiannis Georgios Th, Grivas Ioannis, Tsingotjidou Anastasia, Apostolidis Georgios, Tsardaka Eirini, Dori Ioanna, Poulatsidou Kyriaki-Nefeli, Tsougos Ioannis, Wesarg Stefan, Doumas Argyrios, Georgoulias Panagiotis

机构信息

"ORMYLIA" Foundation, 63071 Ormylia, Greece.

Diagnosis Multisystems, 63200 Nea Moudania, Greece.

出版信息

Cancers (Basel). 2025 Aug 7;17(15):2599. doi: 10.3390/cancers17152599.

DOI:10.3390/cancers17152599
PMID:40805294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12345681/
Abstract

This study proposes a novel diagnostic system for the early detection of cutaneous melanoma based on morphological and biochemical changes during tumor formation. The methods used in this system are acoustic microscopy and infrared (IR) spectroscopy. The former identifies the anatomical parameters of the developing tumor, whilst the latter identifies its biochemical features, both at the micron scale. To implement this diagnostic method, an animal model that mimics human melanoma was developed. The results of this investigation show that using high-frequency (>20 MHz) acoustic microscopy in conjunction with spectroscopic images provides useful information about distinct features of melanoma tumors' 3D structures. The structures and cytoarchitecture of the tumors were assessed using conventional histology, and their malignant nature was confirmed using histological and immumohistochemical analysis. The proposed approach may provide an invaluable tool in diagnostic dermatology, as it is noninvasive and produces highly detailed and accurate data about the early appearance and development of melanoma tumors.

摘要

本研究基于肿瘤形成过程中的形态学和生化变化，提出了一种用于早期检测皮肤黑色素瘤的新型诊断系统。该系统所采用的方法是声学显微镜和红外（IR）光谱法。前者在微米尺度上识别正在形成的肿瘤的解剖学参数，而后者识别其生化特征。为实施这种诊断方法，开发了一种模拟人类黑色素瘤的动物模型。本研究结果表明，将高频（>20 MHz）声学显微镜与光谱图像结合使用，可提供有关黑色素瘤肿瘤三维结构独特特征的有用信息。使用传统组织学评估肿瘤的结构和细胞结构，并通过组织学和免疫组织化学分析确认其恶性性质。所提出的方法可能为诊断皮肤病学提供一种宝贵的工具，因为它是非侵入性的，并且能产生关于黑色素瘤肿瘤早期出现和发展的高度详细和准确的数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/3b1ce75e9079/cancers-17-02599-g023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/a2aeb07a8e85/cancers-17-02599-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/8d02b28fcf37/cancers-17-02599-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/e03628104da9/cancers-17-02599-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/8a4c6f4832da/cancers-17-02599-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/be06e46e2d4d/cancers-17-02599-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/aedc3c424a07/cancers-17-02599-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/b04f7eb24eae/cancers-17-02599-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/8dc9420162c0/cancers-17-02599-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/320a282274ca/cancers-17-02599-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/7ba454de7437/cancers-17-02599-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/9e407c43655a/cancers-17-02599-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/88efb9311cba/cancers-17-02599-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/b491fa600ac1/cancers-17-02599-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/2aed46351f07/cancers-17-02599-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/4002ca003445/cancers-17-02599-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/f524de8c5b85/cancers-17-02599-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/7990246a3895/cancers-17-02599-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/e8cda542b3d2/cancers-17-02599-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/69568045a923/cancers-17-02599-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/3b83b822ba39/cancers-17-02599-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/0fe3c2ceccb5/cancers-17-02599-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/4d96110d485d/cancers-17-02599-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/3b1ce75e9079/cancers-17-02599-g023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/a2aeb07a8e85/cancers-17-02599-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/8d02b28fcf37/cancers-17-02599-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/e03628104da9/cancers-17-02599-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/8a4c6f4832da/cancers-17-02599-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/be06e46e2d4d/cancers-17-02599-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/aedc3c424a07/cancers-17-02599-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/b04f7eb24eae/cancers-17-02599-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/8dc9420162c0/cancers-17-02599-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/320a282274ca/cancers-17-02599-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/7ba454de7437/cancers-17-02599-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/9e407c43655a/cancers-17-02599-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/88efb9311cba/cancers-17-02599-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/b491fa600ac1/cancers-17-02599-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/2aed46351f07/cancers-17-02599-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/4002ca003445/cancers-17-02599-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/f524de8c5b85/cancers-17-02599-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/7990246a3895/cancers-17-02599-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/e8cda542b3d2/cancers-17-02599-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/69568045a923/cancers-17-02599-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/3b83b822ba39/cancers-17-02599-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/0fe3c2ceccb5/cancers-17-02599-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/4d96110d485d/cancers-17-02599-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ee0/12345681/3b1ce75e9079/cancers-17-02599-g023.jpg

相似文献

1
Diagnostic System for Early In Situ Melanoma Detection Using Acoustic Microscopy and Infrared Spectroscopic Mapping Imaging.基于声学显微镜和红外光谱映射成像的早期原位黑色素瘤诊断系统
Cancers (Basel). 2025 Aug 7;17(15):2599. doi: 10.3390/cancers17152599.
2
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
3
Short-Term Memory Impairment短期记忆障碍
4
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.在基层医疗机构或医院门诊环境中，如果患者出现以下症状和体征，可判断其是否患有 COVID-19。
Cochrane Database Syst Rev. 2022 May 20;5(5):CD013665. doi: 10.1002/14651858.CD013665.pub3.
5
Sexual Harassment and Prevention Training性骚扰与预防培训
6
Novel application of metabolic imaging of early embryos using a light-sheet on-a-chip device: a proof-of-concept study.使用片上光片装置对早期胚胎进行代谢成像的新应用：一项概念验证研究。
Hum Reprod. 2025 Jan 1;40(1):41-55. doi: 10.1093/humrep/deae249.
7
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
8
Intravenous magnesium sulphate and sotalol for prevention of atrial fibrillation after coronary artery bypass surgery: a systematic review and economic evaluation.静脉注射硫酸镁和索他洛尔预防冠状动脉搭桥术后房颤：系统评价与经济学评估
Health Technol Assess. 2008 Jun;12(28):iii-iv, ix-95. doi: 10.3310/hta12280.
9
Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults.用于检测成人肺结核及利福平耐药性的Xpert® MTB/RIF检测法
Cochrane Database Syst Rev. 2014 Jan 21;2014(1):CD009593. doi: 10.1002/14651858.CD009593.pub3.
10
The Black Book of Psychotropic Dosing and Monitoring.《精神药物剂量与监测黑皮书》
Psychopharmacol Bull. 2024 Jul 8;54(3):8-59.

本文引用的文献

1
Can infrared light really be doing what we claim it is doing? Infrared light penetration principles, practices, and limitations.红外光真的能起到我们所宣称的作用吗？红外光的穿透原理、应用及局限性。
Front Neurol. 2024 Aug 28;15:1398894. doi: 10.3389/fneur.2024.1398894. eCollection 2024.
2
Non-invasive 3D imaging of human melanocytic lesions by combined ultrasound and photoacoustic tomography: a pilot study.联合超声和光声断层扫描对人体黑色素病变的无创 3D 成像：一项初步研究。
Sci Rep. 2024 Feb 2;14(1):2768. doi: 10.1038/s41598-024-53220-y.
3
Cancer statistics, 2024.
2024年癌症统计数据。
CA Cancer J Clin. 2024 Jan-Feb;74(1):12-49. doi: 10.3322/caac.21820. Epub 2024 Jan 17.
4
Ultrasound of Skin Cancer: What We Need to Know.皮肤癌的超声检查：我们需要了解的内容。
Semin Ultrasound CT MR. 2024 Jun;45(3):216-232. doi: 10.1053/j.sult.2023.11.003. Epub 2023 Dec 4.
5
Raman-Based Techniques in Medical Applications for Diagnostic Tasks: A Review.基于拉曼的技术在医学诊断任务中的应用：综述。
Int J Mol Sci. 2023 Oct 26;24(21):15605. doi: 10.3390/ijms242115605.
6
Combined ultrasound and photoacoustic C-mode imaging system for skin lesion assessment.用于皮肤病变评估的超声与光声C模式联合成像系统。
Sci Rep. 2023 Oct 20;13(1):17947. doi: 10.1038/s41598-023-44919-5.
7
Drug delivery by sonosensitive liposome and microbubble with acoustic-lens attached ultrasound: an in vivo feasibility study in a murine melanoma model.声敏脂质体和微泡联合声透镜超声给药：在小鼠黑素瘤模型中的体内可行性研究。
Sci Rep. 2023 Sep 22;13(1):15798. doi: 10.1038/s41598-023-42786-8.
8
The effects of infrared radiation on the human skin.红外辐射对人体皮肤的影响。
Photodermatol Photoimmunol Photomed. 2023 Nov;39(6):549-555. doi: 10.1111/phpp.12899. Epub 2023 Jul 11.
9
Cancer statistics, 2023.癌症统计数据，2023 年。
CA Cancer J Clin. 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763.
10
Multimodal system for optical biopsy of melanoma with integrated ultrasound, optical coherence tomography and Raman spectroscopy.用于黑色素瘤光学活检的多模态系统，集成了超声、光学相干断层扫描和拉曼光谱技术。
J Biophotonics. 2022 Oct;15(10):e202200129. doi: 10.1002/jbio.202200129. Epub 2022 Jul 20.