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非洲爪蟾卵母细胞中Alu序列的转录：核质分配及3'端加工反应的证据

Alu sequences transcription in X. laevis oocytes: nuclear-cytoplasmic partitioning and evidence for 3' end processing reactions.

作者信息

Perlino E, Paonessa G, Ciliberto G

出版信息

Nucleic Acids Res. 1985 Dec 9;13(23):8359-77. doi: 10.1093/nar/13.23.8359.

DOI:10.1093/nar/13.23.8359
PMID:4080545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC322139/
Abstract

A large Alu-family cluster in the 5' flanking region of a human alpha 1-acid glycoprotein gene has been identified and sequenced. Individual members microinjected into X. laevis oocytes are transcribed only when canonical box A and B components of the split pol III promoter are present. Alu transcripts accumulate in the nucleus. An unusually short Alu transcript, able to assume a stable secondary structure, undergoes a 3' end processing reaction similar to the one required for tRNA 3' end maturation.

摘要

已鉴定并测序了人类α1-酸性糖蛋白基因5'侧翼区域中的一个大型Alu家族簇。微注射到非洲爪蟾卵母细胞中的单个成员只有在存在分裂型RNA聚合酶III启动子的典型A盒和B盒元件时才会转录。Alu转录本在细胞核中积累。一种异常短的Alu转录本能够形成稳定的二级结构，其3'末端加工反应类似于tRNA 3'末端成熟所需的反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/77bb387881eb/nar00317-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/5b76928f1070/nar00317-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/b53270053ec3/nar00317-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/990e9bb44616/nar00317-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/dc4f6bafe784/nar00317-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/30b52cbd4c1c/nar00317-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/77bb387881eb/nar00317-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/5b76928f1070/nar00317-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/b53270053ec3/nar00317-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/990e9bb44616/nar00317-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/dc4f6bafe784/nar00317-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/30b52cbd4c1c/nar00317-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af7/322139/77bb387881eb/nar00317-0085-a.jpg

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本文引用的文献

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Mol Cell Biol. 1981 Jul;1(7):573-83. doi: 10.1128/mcb.1.7.573-583.1981.
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Transcriptional analysis of interspersed repetitive polymerase III transcription units in human DNA.人类DNA中散布的重复聚合酶III转录单位的转录分析。
Nucleic Acids Res. 1981 Mar 11;9(5):1171-89. doi: 10.1093/nar/9.5.1171.
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Repetitive sequences in eukaryotic DNA and their expression.
HSAG-1的结构，一种引发白血病相关细胞表面抗原的中度重复遗传元件。
Nucleic Acids Res. 1986 Apr 25;14(8):3409-24. doi: 10.1093/nar/14.8.3409.
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Construction of a NotI linking library and isolation of new markers close to the Huntington's disease gene.构建NotI连接文库并分离与亨廷顿舞蹈病基因相邻的新标记
Nucleic Acids Res. 1988 Oct 11;16(19):9185-98. doi: 10.1093/nar/16.19.9185.
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Identification of an essential Schizosaccharomyces pombe RNA homologous to the 7SL component of signal recognition particle.鉴定出一种与信号识别颗粒的7SL组分同源的粟酒裂殖酵母必需RNA。
Mol Cell Biol. 1988 Apr;8(4):1580-90. doi: 10.1128/mcb.8.4.1580-1590.1988.
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Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8302-6. doi: 10.1073/pnas.88.19.8302.
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