Baek Yujin, Nguyen Ngoc Ha, Lee Young In, Jung Min Joo, Kim In Ah, Lee Sung Jun, Kim Hyun Min, Lee Ju Hee
Department of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Department of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 17000, Vietnam.
Int J Mol Sci. 2025 Jul 28;26(15):7291. doi: 10.3390/ijms26157291.
Skin aging causes reduced hydration, elasticity, and increased wrinkles. Recent safety and compliance concerns over oral collagen supplements have increased interest in plant-based alternatives like with antioxidant and anti-aging properties. However, clinical evidence regarding its efficacy remains limited. We aimed to evaluate the effects of this plant-based collagen alternative (VC-H1, Hibiscus Enzyme Extract) supplement on skin hydration, transepidermal water loss (TEWL), desquamation, elasticity, and wrinkle reduction in photoaged individuals. A randomized, double-blind, placebo-controlled clinical trial was conducted with 98 participants (aged 35-60 years) presenting with dry skin and periorbital wrinkles. Participants randomly received 1.5 g/day of VC-H1 or placebo for 12 weeks. Skin hydration, TEWL, deep moisture, keratin index, elasticity, and wrinkle parameters were assessed at baseline, 6 weeks, and 12 weeks. VC-H1 supplementation significantly increased skin hydration, reduced the TEWL and keratin index, and improved deep moisture content for those receiving it compared with the controls. Wrinkle depth significantly decreased, and skin elasticity also improved. Those in the VC-H1 group showed greater overall improvement than those in the control group. Oral VC-H1 supplementation significantly improved skin hydration, elasticity, and wrinkle reduction, suggesting its potential as a plant-based alternative to traditional collagen supplements for skin rejuvenation.
皮肤老化会导致水分流失、弹性降低以及皱纹增多。近期，人们对口服胶原蛋白补充剂的安全性和合规性有所担忧，这使得对具有抗氧化和抗老化特性的植物性替代品的兴趣增加。然而，关于其功效的临床证据仍然有限。我们旨在评估这种植物性胶原蛋白替代品（VC-H1，木槿酶提取物）补充剂对光老化个体的皮肤水分、经表皮水分流失（TEWL）、脱屑、弹性和皱纹减少的影响。对98名（年龄在35至60岁之间）有干性皮肤和眶周皱纹的参与者进行了一项随机、双盲、安慰剂对照临床试验。参与者随机接受每天1.5克的VC-H1或安慰剂，为期12周。在基线、6周和12周时评估皮肤水分、TEWL、深层水分、角蛋白指数、弹性和皱纹参数。与对照组相比，补充VC-H1显著增加了接受者的皮肤水分，降低了TEWL和角蛋白指数，并改善了深层水分含量。皱纹深度显著降低，皮肤弹性也有所改善。VC-H1组的总体改善程度高于对照组。口服VC-H1补充剂显著改善了皮肤水分、弹性和皱纹减少，表明其作为传统胶原蛋白补充剂的植物性替代品用于皮肤年轻化的潜力。
