Akter Tahmina, Maqsood Hajra, Castilla Nicholas, Song Wenyuan, Chen Sixue
Department of Biology, University of Mississippi, Oxford, MS 38677, USA.
Department of Plant Pathology, University of Florida, Gainesville, FL 32611, USA.
Int J Mol Sci. 2025 Jul 29;26(15):7318. doi: 10.3390/ijms26157318.
Plant diseases resulting from pathogens and pests constitute a persistent threat to global food security. Pathogenic infections of plants are influenced by environmental factors; a concept encapsulated in the "disease triangle" model. It is important to elucidate the complex molecular mechanisms underlying the interactions among plants, their pathogens and various environmental factors in the disease triangle. This review aims to highlight recent advancements in the application of systems biology to enhance understanding of the plant disease triangle within the context of microbiome rising to become the 4th dimension. Recent progress in microbiome research utilizing model plant species has begun to illuminate the roles of specific microorganisms and the mechanisms of plant-microbial interactions. We will examine (1) microbiome-mediated functions related to plant growth and protection, (2) advancements in systems biology, (3) current -omics methodologies and new approaches, and (4) challenges and future perspectives regarding the exploitation of plant defense mechanisms via microbiomes. It is posited that systems biology approaches such as single-cell RNA sequencing and mass spectrometry-based multi-omics can decode plant defense mechanisms. Progress in this significant area of plant biology has the potential to inform rational crop engineering and breeding strategies aimed at enhancing disease resistance without compromising other pathways that affect crop yield.
由病原体和害虫引起的植物病害对全球粮食安全构成持续威胁。植物的病原感染受环境因素影响，这一概念包含在“病害三角”模型中。阐明病害三角中植物、病原体和各种环境因素之间相互作用背后的复杂分子机制很重要。本综述旨在突出系统生物学应用方面的最新进展，以在微生物群落上升为第四维度的背景下，增进对植物病害三角的理解。利用模式植物物种进行的微生物群落研究的最新进展已开始阐明特定微生物的作用以及植物 - 微生物相互作用的机制。我们将研究（1）与植物生长和保护相关的微生物群落介导的功能，（2）系统生物学的进展，（3）当前的组学方法和新方法，以及（4）通过微生物群落利用植物防御机制的挑战和未来展望。有人认为，单细胞RNA测序和基于质谱的多组学等系统生物学方法可以解码植物防御机制。植物生物学这一重要领域的进展有可能为合理的作物工程和育种策略提供信息，旨在增强抗病性而不损害影响作物产量的其他途径。
