1-S-苯基硫代乙醇腈新衍生物的合成及某些生物学性质
Synthesis and some biological properties of new derivatives of 1-S-phenylthioglycolonitrile.
作者信息
Makosza M, Ludwikow M, Ernest K, Bogdal M, Przemyk B, Filczewski M, Oledzka K
出版信息
Pol J Pharmacol Pharm. 1985 Jul-Aug;37(4):551-63.
PMID:4080649
Abstract
A series of new S-phenylthioglycolic acid derivatives was synthetized via common transformations of alkylated S-phenyl-thioglycolonitrile. The compounds were submitted to pharmacological screening. N,N-Diethylaminoethyl ester of 1-S-phenylcyclopentane carboxylic acid was submitted to detailed studies and showed high local anesthetic properties.
摘要
通过烷基化S-苯基硫代乙腈的常见转化反应合成了一系列新的S-苯基硫代乙醇酸衍生物。这些化合物进行了药理筛选。对1-S-苯基环戊烷羧酸的N,N-二乙氨基乙酯进行了详细研究，结果显示其具有较高的局部麻醉特性。
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