Shurtleff D B, Stuntz J T, Hayden P W
Pediatr Neurosci. 1985;12(1):49-57. doi: 10.1159/000120218.
This report of our experience with 1,201 cerebrospinal fluid shunt procedures over a 17-year period includes two time periods: from 1965 to 1974 and from 1975 to 1982. The overall operative infection rate fell from 10.7% in the former period to 3.6% in the latter period. The overall average number of revisions fell from 1.8 to 0.77. The number of revisions for patients with infected shunts in the latter period was 4.07. Three hundred and eighty-four shunts were studied in the latter period for the effects of prophylactic antibiotics. No significant difference was found between the infection rate of 5.6% in the nonantibiotic group and the infection rate of 2.1% in the group receiving intravenous and intraventricular methicillin and gentamicin. Differences in the operative infection rates for patients with and without meningomyelocele and those operated on by different surgeons were not significant. The only mortalities were from nonoperative and noncerebrospinal fluid shunt causes.
这份关于我们在17年期间进行的1201例脑脊液分流手术经验的报告涵盖两个时间段：1965年至1974年以及1975年至1982年。总体手术感染率从前一时期的10.7%降至后一时期的3.6%。总体平均修复次数从1.8次降至0.77次。后一时期感染分流患者的修复次数为4.07次。在后一时期对384例分流手术进行了预防性抗生素效果研究。未使用抗生素组5.6%的感染率与接受静脉及脑室内注射甲氧西林和庆大霉素组2.1%的感染率之间未发现显著差异。患有和未患脊髓脊膜膨出的患者以及由不同外科医生实施手术的患者，其手术感染率差异不显著。仅有的死亡病例是由非手术及非脑脊液分流相关原因导致的。
