Korolova Daria, Suranyi Andrea, Pavlenko Anastasiia, Altorjay Abel T, Zhuk Svitlana, Us Iryna, Melnyk Yurii, Chernyshenko Volodymyr, Vari Sandor G
Palladin Institute of Biochemistry of NAS of Ukraine, 01054 Kyiv, Ukraine.
Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.
J Clin Med. 2025 Jul 28;14(15):5310. doi: 10.3390/jcm14155310.
: Pregnancy is associated with increased procoagulant conditions, and when combined with obesity, it can elevate the risk of thrombosis. The study aims to assess thrombosis risk markers during pregnancy in relation to obesity. : Somatically healthy women aged 18-42 years with spontaneous pregnancies who did not receive specific antithrombotic treatment were enrolled in the study (n = 97). The participants were divided into groups based on pregestational BMI: the first group consisted of patients who had a BMI ≤ 25 (n = 42), and the second group consisted of patients who were overweight (BMI > 25) and obese (BMI > 30) (n = 55). The control group comprised healthy, non-pregnant, non-obese women (n = 10). : Fibrinogen levels, elevated during pregnancy, were higher in the II and III trimesters, with gestational period having a greater influence than BMI. Moderate D-dimer accumulation was observed regardless of obesity, but higher levels were seen in obese women during the III trimester, indicating the dissolution of intravascular fibrin deposits. Soluble fibrin was significantly higher in obese and overweight women during the II trimester and elevated in both groups during the III trimester, correlating with D-dimer accumulation and indicating thrombus formation. A decrease in platelet aggregation ability was observed correlating with D-dimer and soluble fibrin patterns. : A significant accumulation of thrombosis risk markers was observed in the III trimester compared to the II, occurring earlier in obese and overweight pregnant women and indicating a higher risk of thrombotic complications in obesity.
妊娠与促凝状态增加有关，与肥胖相结合时，会增加血栓形成的风险。本研究旨在评估妊娠期间与肥胖相关的血栓形成风险标志物。
纳入本研究的是18 - 42岁自然受孕且未接受特定抗血栓治疗的身体健康女性（n = 97）。参与者根据孕前BMI分组：第一组由BMI≤25的患者组成（n = 42），第二组由超重（BMI>25）和肥胖（BMI>30）的患者组成（n = 55）。对照组包括健康、未怀孕、非肥胖女性（n = 10）。
妊娠期间升高的纤维蛋白原水平在孕中期和孕晚期更高，孕期的影响大于BMI。无论肥胖情况如何，均观察到中度D - 二聚体积累，但肥胖女性在孕晚期的水平更高，表明血管内纤维蛋白沉积物的溶解。可溶性纤维蛋白在肥胖和超重女性的孕中期显著更高，且在两组的孕晚期均升高，与D - 二聚体积累相关，表明血栓形成。观察到血小板聚集能力下降，与D - 二聚体和可溶性纤维蛋白模式相关。
与孕中期相比，孕晚期观察到血栓形成风险标志物显著积累，在肥胖和超重孕妇中出现得更早，表明肥胖患者发生血栓并发症的风险更高。
