Shen Juanli, Fu Shiyu, Liu Xiaohong, Tian Shenglong, Yi ZeDe, Wang Ying
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, P. R. China.
CAS Key Laboratory of Science and Technology on Applied Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, P. R. China.
Adv Healthc Mater. 2025 Jun;14(15):e2500600. doi: 10.1002/adhm.202500600. Epub 2025 May 2.
Conventional wound dressings frequently face challenges of insufficient mechanical strength, inadequate adhesion, irregular drug release, and contamination from adherence to extraneous surfaces. These issues can lead to wound contamination and the risk of secondary injuries. In this work, a robust, thermoresponsive wound dressing is developed based on pH/thermal-responsive supramolecular hydrogels, synthesized by integrating N-isopropyl acrylamide, carboxymethyl cellulose, and β-cyclodextrin-grafted poly(acrylic acid). The novel finding is that the hydrogel exhibits a Janus-like adhesion, wherein it adheres stably to the wound while losing adhesion to external environments resulting in reduced accumulation of impurities. The prepared hydrogels can self-heal at low temperatures. It has antioxidant properties and excellent biocompatibility that can continuously and stably release active medicines. In vivo experiments in a rat model of full-thickness skin wounds show that the hydrogels positively accelerate wound healing. The unique physicochemical properties and biological interactions of this multifunctional supramolecular hydrogel provide a promise for advancing wound management by modulating tissue adhesion.
传统伤口敷料常常面临机械强度不足、粘附性不够、药物释放不规则以及因粘附到外部表面而受到污染等挑战。这些问题会导致伤口感染以及二次受伤的风险。在这项工作中，基于pH/热响应超分子水凝胶开发了一种坚固的热响应伤口敷料，该水凝胶通过整合N-异丙基丙烯酰胺、羧甲基纤维素和β-环糊精接枝聚丙烯酸合成。新发现是该水凝胶表现出类雅努斯粘附性，即它能稳定地粘附在伤口上，同时失去与外部环境的粘附性，从而减少杂质积累。制备的水凝胶在低温下能够自我愈合。它具有抗氧化性能和出色的生物相容性，能够持续稳定地释放活性药物。在大鼠全层皮肤伤口模型中的体内实验表明，该水凝胶能积极促进伤口愈合。这种多功能超分子水凝胶独特的物理化学性质和生物相互作用为通过调节组织粘附推进伤口管理带来了希望。
