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[荷瘤小鼠骨髓和脾脏中克隆形成性粒细胞巨噬细胞前体细胞的放射敏感性]

[Radiosensitivity of clonogenic granulocytic macrophage cell precursors in the bone marrow and spleen of tumor-bearing mice].

作者信息

Lepekhina L A, Kolesnikova A I, Konopliannikov A G

出版信息

Radiobiologiia. 1985 Nov-Dec;25(6):752-5.

PMID:4080992
Abstract

Clonogenic granulocytic macrophagal cells-precursors (CFU-DC) of bone marrow and spleen of intact C57Bl/6 mice and those inoculated subcutaneously with LLC tumor cells do not substantially differ in their radiosensitivity; the concentration of CFU-DC in the spleen markedly varies as tumor grows. The values of Do and extrapolation number n for CFU-DC of the bone marrow are 0.9-1.4 and 1.5-3.0 Gy, and of the spleen, 0.8-1.6 and 1.0-2.6 Gy, respectively.

摘要

完整的C57Bl/6小鼠以及皮下接种LLC肿瘤细胞的小鼠，其骨髓和脾脏中的克隆形成性粒巨噬细胞前体（CFU-DC）的放射敏感性无显著差异；随着肿瘤生长，脾脏中CFU-DC的浓度显著变化。骨髓CFU-DC的Do值和外推数n分别为0.9 - 1.4 Gy和1.5 - 3.0 Gy，脾脏CFU-DC的Do值和外推数n分别为0.8 - 1.6 Gy和1.0 - 2.6 Gy。

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