Griffin David W J, McMahon J H, Ruschena D A, Hoy J F
Department of Infectious Diseases, Alfred Health and Monash University, Melbourne, Victoria, Australia.
School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
HIV Med. 2025 Nov;26(11):1632-1645. doi: 10.1111/hiv.70099. Epub 2025 Aug 15.
People with HIV experience disparate access to solid organ transplantation (SOT), despite mounting evidence for comparable outcomes. This review aims to understand the outcomes following SOT, obstacles to SOT and opportunities to improve access and outcomes following SOT.
We conducted a narrative review of the literature.
SOT is safe and effective for people with HIV, and increasing evidence indicates that people with HIV may safely donate organs to others with HIV. People with HIV experience a higher risk of acute rejection following SOT, without a higher risk of graft loss or death, when compared with appropriately matched controls. Those with HIV experience systemic and structural barriers to SOT, in addition to barriers that occur at the level of healthcare providers and consumers. Opportunities exist to improve access to SOT, and to improve SOT-related care for people with HIV.
SOT should be considered standard of care for people with HIV when indicated. Further efforts are required to identify and address gaps in the SOT-related cascade of care; and to improve SOT outcomes for people with HIV.
尽管越来越多的证据表明实体器官移植（SOT）对人类免疫缺陷病毒（HIV）感染者的预后相当，但HIV感染者获得SOT的机会却存在差异。本综述旨在了解SOT后的预后情况、SOT的障碍以及改善SOT机会和预后的机遇。
我们对文献进行了叙述性综述。
SOT对HIV感染者是安全有效的，越来越多的证据表明，HIV感染者可以安全地将器官捐赠给其他HIV感染者。与匹配适当的对照组相比，HIV感染者在SOT后发生急性排斥反应的风险更高，但移植物丢失或死亡的风险并未增加。HIV感染者在SOT方面面临系统性和结构性障碍，此外还面临医疗服务提供者和患者层面的障碍。存在改善获得SOT的机会，以及改善HIV感染者SOT相关护理的机会。
在有指征时，SOT应被视为HIV感染者的标准治疗方法。需要进一步努力识别和解决SOT相关护理连续过程中的差距；并改善HIV感染者的SOT预后。
