Ajalcriña-Martensen A-A, Minchón-Medina C-A, Astigueta-Perez J, Gamboa-Vicente W-G, Ganoza-Larrea L-J, Asmat-Abanto A-S
3145 America Sur Avenue Monserrate Neighborhood Trujillo, 13008, Peru
Med Oral Patol Oral Cir Bucal. 2025 Sep 1;30(5):e681-e689. doi: 10.4317/medoral.27179.
Periodontitis triggers systemic inflammatory reactions that may be associated with different oncological diseases, such as prostate cancer (PC), although little information exists on the possibility of this association. To determine whether periodontitis is associated with PC and other non-metastatic urological cancers in patients over 50.
This cross-sectional study was conducted between August and September 2024 at the outpatient clinic of the Belén de Trujillo Hospital (HBT) and the Regional Institute of Neoplastic Diseases "Dr. Luis Pinillos Ganoza" - IREN Norte (IREN), in Trujillo, Peru. In total, 192 patients were evaluated: 64 with PC, 64 with non-prostatic urological cancer (NPUC), and 64 with non-oncological urological disease (NOUD). Reliability was determined through inter- and intra-evaluator calibration to diagnose periodontitis, gingivitis inflammation, and plaque control. The corresponding specialist physician diagnosed PC, NPUC, and NOUD. Statistical analysis was performed using the Chi-square and Kruskal-Wallis tests, including nonparametric multiple comparison tests, with a significance level of p<0.05.
An association between periodontitis and PC was found in patients over 50. PC was also directly associated with moderate periodontitis (p=0.014) and generalized gingivitis inflammation (p=0.019). Concerning NPUC, an association was found with periodontal pockets of 3.5 - 5.5 mm (p=0.031) and last visit to the dentist more than one year ago (p=0.012).
There was an association between periodontitis and PC in patients over 50. Patients with moderate periodontitis and generalized GI were more likely to present PC compared with patients with NOUD. In addition, there was a greater probability of presenting PC versus NPUC in patients with periodontal pockets of 3.5-5.5 mm and in those whose last visit to the dentist was more than one year ago.
牙周炎会引发全身炎症反应，这可能与不同的肿瘤疾病相关，如前列腺癌（PC），尽管关于这种关联可能性的信息很少。为了确定50岁以上患者的牙周炎是否与PC及其他非转移性泌尿系统癌症有关。
这项横断面研究于2024年8月至9月在秘鲁特鲁希略的贝伦德特鲁希略医院（HBT）门诊和“路易斯·皮尼洛斯·加诺萨博士”肿瘤疾病区域研究所 - 北IREN（IREN）进行。总共评估了192名患者：64名患有PC，64名患有非前列腺泌尿系统癌症（NPUC），64名患有非肿瘤性泌尿系统疾病（NOUD）。通过评估者间和评估者内校准来确定诊断牙周炎、牙龈炎炎症和菌斑控制的可靠性。相应的专科医生诊断PC、NPUC和NOUD。使用卡方检验和克鲁斯卡尔 - 沃利斯检验进行统计分析，包括非参数多重比较检验，显著性水平为p<0.05。
在50岁以上患者中发现牙周炎与PC之间存在关联。PC还与中度牙周炎（p = 0.014）和广泛性牙龈炎炎症（p = 0.019）直接相关。关于NPUC，发现与3.5 - 5.5毫米的牙周袋（p = 0.031）以及最后一次看牙医超过一年前（p = 0.012）有关联。
50岁以上患者的牙周炎与PC之间存在关联。与患有NOUD的患者相比，患有中度牙周炎和广泛性牙龈炎炎症的患者更有可能患PC。此外，在牙周袋为3.5 - 5.5毫米的患者以及最后一次看牙医超过一年前的患者中，患PC的可能性高于患NPUC的可能性。
